Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations
Oxidative stress arising from reactive oxygen and nitrogen species (RONS) imposes a severe threat to living organisms by causing extensive cellular and subcellular damage. Environmental pollutants (e.g., xenoestrogens, pesticides, heavy metals, and polycyclic aromatic hydrocarbons) further amplify R...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Nano TransMed |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2790676025000184 |
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| author | Hamieh Goshtasbi Nastaran Hashemzadeh Marziyeh Fathi Ali Movafeghi Jaleh Barar Yadollah Omidi |
| author_facet | Hamieh Goshtasbi Nastaran Hashemzadeh Marziyeh Fathi Ali Movafeghi Jaleh Barar Yadollah Omidi |
| author_sort | Hamieh Goshtasbi |
| collection | DOAJ |
| description | Oxidative stress arising from reactive oxygen and nitrogen species (RONS) imposes a severe threat to living organisms by causing extensive cellular and subcellular damage. Environmental pollutants (e.g., xenoestrogens, pesticides, heavy metals, and polycyclic aromatic hydrocarbons) further amplify RONS generation, disrupting mitochondrial function and triggering chronic inflammation. Mitochondrial dysfunction not only hinders energy metabolism but also facilitates the release of pro-apoptotic factors (e.g., cytochrome c), ultimately leading to programmed cell death. Consequently, heightened oxidative stress and mitochondrial impairment are key contributors to a range of chronic illnesses, including metabolic, cardiovascular, endocrine, reproductive, neurodegenerative diseases like Alzheimer’s disease, and cancer. While exogenous antioxidants have shown potential in neutralizing RONS and alleviating oxidative damage, clinical applications are hampered by poor bioavailability, instability, and limited cellular uptake. Antioxidant nanoformulations, particularly those employing biodegradable lipidic and polymeric nanocarriers, offer a promising strategy to address these challenges. Formulated nanoscale delivery systems and bioengineered nanocarriers have been developed for the delivery of antioxidants, which have enhanced antioxidant stability and targeted delivery, and improved therapeutic outcomes. This review discusses the latest advances in nanocarrier-based antioxidant therapies, emphasizing their capacity to mitigate toxicities induced by environmental pollutants and oxidative stress, ultimately opening new prospects for disease management and preventive healthcare. |
| format | Article |
| id | doaj-art-fb92c516b0784134892cdea0c8fc37bf |
| institution | OA Journals |
| issn | 2790-6760 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Nano TransMed |
| spelling | doaj-art-fb92c516b0784134892cdea0c8fc37bf2025-08-20T01:55:37ZengKeAi Communications Co., Ltd.Nano TransMed2790-67602025-12-01410008710.1016/j.ntm.2025.100087Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulationsHamieh Goshtasbi0Nastaran Hashemzadeh1Marziyeh Fathi2Ali Movafeghi3Jaleh Barar4Yadollah Omidi5Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Mechanics and Aerospace Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, ChinaResearch Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, IranResearch Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Plant, Cell and Molecular Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, IranDepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, United StatesDepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, United States; Corresponding author.Oxidative stress arising from reactive oxygen and nitrogen species (RONS) imposes a severe threat to living organisms by causing extensive cellular and subcellular damage. Environmental pollutants (e.g., xenoestrogens, pesticides, heavy metals, and polycyclic aromatic hydrocarbons) further amplify RONS generation, disrupting mitochondrial function and triggering chronic inflammation. Mitochondrial dysfunction not only hinders energy metabolism but also facilitates the release of pro-apoptotic factors (e.g., cytochrome c), ultimately leading to programmed cell death. Consequently, heightened oxidative stress and mitochondrial impairment are key contributors to a range of chronic illnesses, including metabolic, cardiovascular, endocrine, reproductive, neurodegenerative diseases like Alzheimer’s disease, and cancer. While exogenous antioxidants have shown potential in neutralizing RONS and alleviating oxidative damage, clinical applications are hampered by poor bioavailability, instability, and limited cellular uptake. Antioxidant nanoformulations, particularly those employing biodegradable lipidic and polymeric nanocarriers, offer a promising strategy to address these challenges. Formulated nanoscale delivery systems and bioengineered nanocarriers have been developed for the delivery of antioxidants, which have enhanced antioxidant stability and targeted delivery, and improved therapeutic outcomes. This review discusses the latest advances in nanocarrier-based antioxidant therapies, emphasizing their capacity to mitigate toxicities induced by environmental pollutants and oxidative stress, ultimately opening new prospects for disease management and preventive healthcare.http://www.sciencedirect.com/science/article/pii/S2790676025000184AntioxidantDrug delivery systemNanomedicineNanoparticlesPollutants |
| spellingShingle | Hamieh Goshtasbi Nastaran Hashemzadeh Marziyeh Fathi Ali Movafeghi Jaleh Barar Yadollah Omidi Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations Nano TransMed Antioxidant Drug delivery system Nanomedicine Nanoparticles Pollutants |
| title | Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations |
| title_full | Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations |
| title_fullStr | Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations |
| title_full_unstemmed | Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations |
| title_short | Mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations |
| title_sort | mitigating oxidative stress toxicities of environmental pollutants by antioxidant nanoformulations |
| topic | Antioxidant Drug delivery system Nanomedicine Nanoparticles Pollutants |
| url | http://www.sciencedirect.com/science/article/pii/S2790676025000184 |
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