The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review
(1) Background: This systematic review critically appraises and synthesizes evidence from in vitro studies investigating the effects of curcumin nanoparticles on titanium surface modification, focusing on cell adhesion, proliferation, osteogenic differentiation, and mineralization. (2) Methods: A co...
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MDPI AG
2024-08-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/9/247 |
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| author | Nandita Suresh Matti Mauramo Tuomas Waltimo Timo Sorsa Sukumaran Anil |
| author_facet | Nandita Suresh Matti Mauramo Tuomas Waltimo Timo Sorsa Sukumaran Anil |
| author_sort | Nandita Suresh |
| collection | DOAJ |
| description | (1) Background: This systematic review critically appraises and synthesizes evidence from in vitro studies investigating the effects of curcumin nanoparticles on titanium surface modification, focusing on cell adhesion, proliferation, osteogenic differentiation, and mineralization. (2) Methods: A comprehensive electronic search was conducted in PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar databases, yielding six in vitro studies that met the inclusion criteria. The search strategy and study selection process followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A qualitative methodological assessment was performed using the SciRAP (Science in Risk Assessment and Policy) method, which evaluated the reporting and methodological quality of the included studies. (3) Results: All six studies consistently demonstrated that curcumin-coated titanium surfaces inhibited osteoclastogenesis and promoted osteogenic activity, evidenced by enhanced cell adhesion, proliferation, osteogenic differentiation, and mineralization. The mean reporting quality score was 91.8 (SD = 5.7), and the mean methodological quality score was 85.8 (SD = 10.50), as assessed by the SciRAP method. Half of the studies used hydroxyapatite-coated titanium as a control, while the other half used uncoated titanium, introducing potential variability in baseline comparisons. (4) Conclusions: This systematic review provides compelling in vitro evidence supporting the osteogenic potential of curcumin nanoparticle-coated titanium surfaces. The findings suggest that this surface modification strategy may enhance titanium implants’ biocompatibility and osteogenic properties, potentially improving dental and orthopedic implant outcomes. However, the review highlights significant heterogeneity in experimental designs and a concentration of studies from a single research group. Further research, particularly in vivo studies and clinical trials from diverse research teams, is essential to validate these findings and comprehensively understand the translational potential of this promising surface modification approach. |
| format | Article |
| id | doaj-art-fb9018da3e234863b8048a23bbcf6369 |
| institution | OA Journals |
| issn | 2079-4983 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-fb9018da3e234863b8048a23bbcf63692025-08-20T01:55:34ZengMDPI AGJournal of Functional Biomaterials2079-49832024-08-0115924710.3390/jfb15090247The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic ReviewNandita Suresh0Matti Mauramo1Tuomas Waltimo2Timo Sorsa3Sukumaran Anil4Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki University, 00014 Helsinki, FinlandDepartment of Pathology, Helsinki University Hospital, Helsinki University, 00290 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki University, 00014 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki University, 00014 Helsinki, FinlandOral Health Institute, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar(1) Background: This systematic review critically appraises and synthesizes evidence from in vitro studies investigating the effects of curcumin nanoparticles on titanium surface modification, focusing on cell adhesion, proliferation, osteogenic differentiation, and mineralization. (2) Methods: A comprehensive electronic search was conducted in PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar databases, yielding six in vitro studies that met the inclusion criteria. The search strategy and study selection process followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A qualitative methodological assessment was performed using the SciRAP (Science in Risk Assessment and Policy) method, which evaluated the reporting and methodological quality of the included studies. (3) Results: All six studies consistently demonstrated that curcumin-coated titanium surfaces inhibited osteoclastogenesis and promoted osteogenic activity, evidenced by enhanced cell adhesion, proliferation, osteogenic differentiation, and mineralization. The mean reporting quality score was 91.8 (SD = 5.7), and the mean methodological quality score was 85.8 (SD = 10.50), as assessed by the SciRAP method. Half of the studies used hydroxyapatite-coated titanium as a control, while the other half used uncoated titanium, introducing potential variability in baseline comparisons. (4) Conclusions: This systematic review provides compelling in vitro evidence supporting the osteogenic potential of curcumin nanoparticle-coated titanium surfaces. The findings suggest that this surface modification strategy may enhance titanium implants’ biocompatibility and osteogenic properties, potentially improving dental and orthopedic implant outcomes. However, the review highlights significant heterogeneity in experimental designs and a concentration of studies from a single research group. Further research, particularly in vivo studies and clinical trials from diverse research teams, is essential to validate these findings and comprehensively understand the translational potential of this promising surface modification approach.https://www.mdpi.com/2079-4983/15/9/247curcumin nanoparticlestitaniumsurface modificationosteogenesiscell adhesioncell proliferation |
| spellingShingle | Nandita Suresh Matti Mauramo Tuomas Waltimo Timo Sorsa Sukumaran Anil The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review Journal of Functional Biomaterials curcumin nanoparticles titanium surface modification osteogenesis cell adhesion cell proliferation |
| title | The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review |
| title_full | The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review |
| title_fullStr | The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review |
| title_full_unstemmed | The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review |
| title_short | The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review |
| title_sort | effectiveness of curcumin nanoparticle coated titanium surfaces in osteogenesis a systematic review |
| topic | curcumin nanoparticles titanium surface modification osteogenesis cell adhesion cell proliferation |
| url | https://www.mdpi.com/2079-4983/15/9/247 |
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