Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report
Carcinosarcomas are endometrial neoplasms with malignant epithelial and mesenchymal components. These are rare tumors, corresponding to <5% of uterine cancers. The average age at diagnosis is 65 years and the most characteristic symptom is transvaginal bleeding, common to other uterine tumors. Th...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2023-08-01
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| Series: | Brazilian Journal of Oncology |
| Subjects: | |
| Online Access: | https://www.brazilianjournalofoncology.com.br/details/252/en-US/epithelial-mesenchymal-transition-in-uterine-carcinosarcoma-from-a-dedifferentiated-papillary-serous-carcinoma-to-a-sarcoma--case-report |
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| _version_ | 1850161128343076864 |
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| author | Yago Eloy Souza Barbosa Ana Camila Xavier Lopes Camila Delfino Chaves Régis Ponte Conrado Marcelo Leite Vieira Costa Renato Mazon Lima Verde Leal |
| author_facet | Yago Eloy Souza Barbosa Ana Camila Xavier Lopes Camila Delfino Chaves Régis Ponte Conrado Marcelo Leite Vieira Costa Renato Mazon Lima Verde Leal |
| author_sort | Yago Eloy Souza Barbosa |
| collection | DOAJ |
| description | Carcinosarcomas are endometrial neoplasms with malignant epithelial and mesenchymal components. These are rare tumors, corresponding to <5% of uterine cancers. The average age at diagnosis is 65 years and the most characteristic symptom is transvaginal bleeding, common to other uterine tumors. The definitive diagnosis of the lesion is done by analyzing the surgical specimen and the first-line treatment is surgery with adjuvant chemotherapy and radiotherapy. The authors report a case of a 59-year-old female diagnosed with a uterine carcinosarcoma, whose epithelial component underwent an epithelial-mesenchymal transition. The outstanding aspects of this report are the aggressiveness of this tumor and the presence of a lymph node metastasis by the sarcomatous component, which represents an unusual biological behavior. |
| format | Article |
| id | doaj-art-fb8ee60295b049c4a16f635f09e27eec |
| institution | OA Journals |
| issn | 2526-8732 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-fb8ee60295b049c4a16f635f09e27eec2025-08-20T02:22:56ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322023-08-011910.5935/2526-8732.20230403Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case reportYago Eloy Souza Barbosa0Ana Camila Xavier Lopes1Camila Delfino Chaves2Régis Ponte Conrado3Marcelo Leite Vieira Costa4Renato Mazon Lima Verde Leal5Federal University of Ceará (UFC), Medical School - Fortaleza - CE - BrazilFederal University of Ceará (UFC), Medical School - Fortaleza - CE - BrazilFederal University of Ceará (UFC), Medical School - Fortaleza - CE - BrazilFederal University of Ceará (UFC), Medical School - Fortaleza - CE - BrazilWalter Cantídio Universitary Hospital (HUWC), Surgical Oncology Service - Fortaleza - CE - BrazilWalter Cantídio Universitary Hospital (HUWC), Surgical Oncology Service - Fortaleza - CE - BrazilCarcinosarcomas are endometrial neoplasms with malignant epithelial and mesenchymal components. These are rare tumors, corresponding to <5% of uterine cancers. The average age at diagnosis is 65 years and the most characteristic symptom is transvaginal bleeding, common to other uterine tumors. The definitive diagnosis of the lesion is done by analyzing the surgical specimen and the first-line treatment is surgery with adjuvant chemotherapy and radiotherapy. The authors report a case of a 59-year-old female diagnosed with a uterine carcinosarcoma, whose epithelial component underwent an epithelial-mesenchymal transition. The outstanding aspects of this report are the aggressiveness of this tumor and the presence of a lymph node metastasis by the sarcomatous component, which represents an unusual biological behavior.https://www.brazilianjournalofoncology.com.br/details/252/en-US/epithelial-mesenchymal-transition-in-uterine-carcinosarcoma-from-a-dedifferentiated-papillary-serous-carcinoma-to-a-sarcoma--case-reportcarcinosarcomamixed tumormullerianepithelial-mesenchymal transitiongynecologysurgical oncology. |
| spellingShingle | Yago Eloy Souza Barbosa Ana Camila Xavier Lopes Camila Delfino Chaves Régis Ponte Conrado Marcelo Leite Vieira Costa Renato Mazon Lima Verde Leal Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report Brazilian Journal of Oncology carcinosarcoma mixed tumor mullerian epithelial-mesenchymal transition gynecology surgical oncology. |
| title | Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report |
| title_full | Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report |
| title_fullStr | Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report |
| title_full_unstemmed | Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report |
| title_short | Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report |
| title_sort | epithelial mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma case report |
| topic | carcinosarcoma mixed tumor mullerian epithelial-mesenchymal transition gynecology surgical oncology. |
| url | https://www.brazilianjournalofoncology.com.br/details/252/en-US/epithelial-mesenchymal-transition-in-uterine-carcinosarcoma-from-a-dedifferentiated-papillary-serous-carcinoma-to-a-sarcoma--case-report |
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