Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective
Abstract Background Thrombosis is a major pediatric health problem with a spectrum of etiologies, clinical presentations, and morbidities. Establishing the diagnosis and treatment of pediatric thrombosis with different site-related presentations may be challenging. This article adapts the high-quali...
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| Format: | Article |
| Language: | English |
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2025-07-01
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| Series: | Thrombosis Journal |
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| Online Access: | https://doi.org/10.1186/s12959-025-00758-0 |
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| author | Galila Mokhtar Ashraf Abdelbaky Amira Adly Dina Ezzat Hanafy Hafez Hoda Hassab Ilham Youssry Iman Ragab Laila M. Sherief Marwa Zakaria Mervat Hesham Mervat Mansour Naglaa shaheen Tarek Omar Rasha Abdel-Raouf Abdelaziz Afifi Sara Makkeyah Sonia Adolf Yasser Amer Heba Hussein Hanan Ibrahim Khaled Salama Ahmad Darwish Leonardo R. Brandao Ivan Florez Gehan Lotfy Abdel Hakeem Khalifa |
| author_facet | Galila Mokhtar Ashraf Abdelbaky Amira Adly Dina Ezzat Hanafy Hafez Hoda Hassab Ilham Youssry Iman Ragab Laila M. Sherief Marwa Zakaria Mervat Hesham Mervat Mansour Naglaa shaheen Tarek Omar Rasha Abdel-Raouf Abdelaziz Afifi Sara Makkeyah Sonia Adolf Yasser Amer Heba Hussein Hanan Ibrahim Khaled Salama Ahmad Darwish Leonardo R. Brandao Ivan Florez Gehan Lotfy Abdel Hakeem Khalifa |
| author_sort | Galila Mokhtar |
| collection | DOAJ |
| description | Abstract Background Thrombosis is a major pediatric health problem with a spectrum of etiologies, clinical presentations, and morbidities. Establishing the diagnosis and treatment of pediatric thrombosis with different site-related presentations may be challenging. This article adapts the high-quality Clinical Practice Guidelines (CPGs) for pediatric thrombosis management to suit the Egyptian healthcare context. Methods The adapted ADAPTE methodology was used to identify the high-quality CPGs published between 2012 and 2023. An expert panel screened, reviewed, and assessed the CPGs and formulated the adapted consensus recommendations based on the best available evidence. Results The final CPG document provides consensus recommendations and implementation tools for managing thrombosis with different etiologies in children and adolescents in Egypt. There is no evidence to support strong recommendations for various management approaches. Conclusions In general, a complete clinical and radiological assessment and some laboratory tests are indicated at the initial diagnosis to confirm a thrombotic disorder and to further choose the type of workup required. Future research should report the outcome of this adapted guideline and include cost-analysis evaluations. |
| format | Article |
| id | doaj-art-fb8e9b19e46d4fa0881a8d5cd799668e |
| institution | Kabale University |
| issn | 1477-9560 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj-art-fb8e9b19e46d4fa0881a8d5cd799668e2025-08-20T04:02:55ZengBMCThrombosis Journal1477-95602025-07-0123111510.1186/s12959-025-00758-0Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspectiveGalila Mokhtar0Ashraf Abdelbaky1Amira Adly2Dina Ezzat3Hanafy Hafez4Hoda Hassab5Ilham Youssry6Iman Ragab7Laila M. Sherief8Marwa Zakaria9Mervat Hesham10Mervat Mansour11Naglaa shaheen12Tarek Omar13Rasha Abdel-Raouf Abdelaziz Afifi14Sara Makkeyah15Sonia Adolf16Yasser Amer17Heba Hussein18Hanan Ibrahim19Khaled Salama20Ahmad Darwish21Leonardo R. Brandao22Ivan Florez23Gehan Lotfy Abdel Hakeem Khalifa24Pediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams UniversityPediatrics and Pediatric Allergy and Immunology, Ain Shams UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams UniversityPediatric Hematology Unit, Pediatric Department, Beni-Suef UniversityNational Cancer Institute, Cairo UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Alexandria UniversityPediatric Hematology Department, Cairo UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig UniversityPediatric Intensive Care, Ain Shams UniversityPediatric Hematology Department, Atfal Masr Health Insurance HospitalPediatrics and Pediatric Neurology Department, Alexandria UniversityPediatric Hematology Department, Cairo UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams UniversityPediatrics Hematology Department, Institute of Medical Research and Clinical Studies, National Research CenterAlexandria Center for Evidence-Based Clinical Practice Guidelines, Alexandria UniversityPeriodontology Department, Faculty of Dentistry, Cairo UniversityPediatric Intensive Care, Ain Shams UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Alexandria UniversityPediatric Hematology and Oncology Unit, Pediatric Department, Mansoura UniversityThe Hospital for Sick Children, University of TorontoDepartment of Pediatrics, University of AntioquiaPediatric Hematology and Oncology Unit, Pediatric Department, Minia UniversityAbstract Background Thrombosis is a major pediatric health problem with a spectrum of etiologies, clinical presentations, and morbidities. Establishing the diagnosis and treatment of pediatric thrombosis with different site-related presentations may be challenging. This article adapts the high-quality Clinical Practice Guidelines (CPGs) for pediatric thrombosis management to suit the Egyptian healthcare context. Methods The adapted ADAPTE methodology was used to identify the high-quality CPGs published between 2012 and 2023. An expert panel screened, reviewed, and assessed the CPGs and formulated the adapted consensus recommendations based on the best available evidence. Results The final CPG document provides consensus recommendations and implementation tools for managing thrombosis with different etiologies in children and adolescents in Egypt. There is no evidence to support strong recommendations for various management approaches. Conclusions In general, a complete clinical and radiological assessment and some laboratory tests are indicated at the initial diagnosis to confirm a thrombotic disorder and to further choose the type of workup required. Future research should report the outcome of this adapted guideline and include cost-analysis evaluations.https://doi.org/10.1186/s12959-025-00758-0ThrombosisManagementPediatric |
| spellingShingle | Galila Mokhtar Ashraf Abdelbaky Amira Adly Dina Ezzat Hanafy Hafez Hoda Hassab Ilham Youssry Iman Ragab Laila M. Sherief Marwa Zakaria Mervat Hesham Mervat Mansour Naglaa shaheen Tarek Omar Rasha Abdel-Raouf Abdelaziz Afifi Sara Makkeyah Sonia Adolf Yasser Amer Heba Hussein Hanan Ibrahim Khaled Salama Ahmad Darwish Leonardo R. Brandao Ivan Florez Gehan Lotfy Abdel Hakeem Khalifa Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective Thrombosis Journal Thrombosis Management Pediatric |
| title | Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective |
| title_full | Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective |
| title_fullStr | Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective |
| title_full_unstemmed | Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective |
| title_short | Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective |
| title_sort | egyptian pediatric guidelines for the management of childhood venous thromboembolism the adapted methodology a limited resource country perspective |
| topic | Thrombosis Management Pediatric |
| url | https://doi.org/10.1186/s12959-025-00758-0 |
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