Disposition Kinetics of Taxanes in Peritoneal Dissemination
Treatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/963403 |
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| _version_ | 1849469343657623552 |
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| author | Ken'ichi Miyamoto Tsutomu Shimada Kazuki Sawamoto Yoshimichi Sai Yutaka Yonemura |
| author_facet | Ken'ichi Miyamoto Tsutomu Shimada Kazuki Sawamoto Yoshimichi Sai Yutaka Yonemura |
| author_sort | Ken'ichi Miyamoto |
| collection | DOAJ |
| description | Treatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal dissemination. They are administered as micellar preparations, Taxol and Taxotere, which consist of paclitaxel in Cremophor EL (crEL) and docetaxel in Polysorbate-80 (PS-80), respectively. In this paper we review the disposition kinetics of taxane anticancer drugs after intraperitoneal administration in peritoneal dissemination patients and animal models and also discuss the effect of the surfactant vehicle on the behavior of taxanes. |
| format | Article |
| id | doaj-art-fb8e02e1980e42d7842b6347b00f05d8 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-fb8e02e1980e42d7842b6347b00f05d82025-08-20T03:25:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/963403963403Disposition Kinetics of Taxanes in Peritoneal DisseminationKen'ichi Miyamoto0Tsutomu Shimada1Kazuki Sawamoto2Yoshimichi Sai3Yutaka Yonemura4Department of Pharmacy, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, JapanDepartment of Pharmacy, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, JapanDepartment of Pharmacy, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, JapanDepartment of Pharmacy, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, JapanDepartment of Pharmacy, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa 920-8641, JapanTreatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal dissemination. They are administered as micellar preparations, Taxol and Taxotere, which consist of paclitaxel in Cremophor EL (crEL) and docetaxel in Polysorbate-80 (PS-80), respectively. In this paper we review the disposition kinetics of taxane anticancer drugs after intraperitoneal administration in peritoneal dissemination patients and animal models and also discuss the effect of the surfactant vehicle on the behavior of taxanes.http://dx.doi.org/10.1155/2012/963403 |
| spellingShingle | Ken'ichi Miyamoto Tsutomu Shimada Kazuki Sawamoto Yoshimichi Sai Yutaka Yonemura Disposition Kinetics of Taxanes in Peritoneal Dissemination Gastroenterology Research and Practice |
| title | Disposition Kinetics of Taxanes in Peritoneal Dissemination |
| title_full | Disposition Kinetics of Taxanes in Peritoneal Dissemination |
| title_fullStr | Disposition Kinetics of Taxanes in Peritoneal Dissemination |
| title_full_unstemmed | Disposition Kinetics of Taxanes in Peritoneal Dissemination |
| title_short | Disposition Kinetics of Taxanes in Peritoneal Dissemination |
| title_sort | disposition kinetics of taxanes in peritoneal dissemination |
| url | http://dx.doi.org/10.1155/2012/963403 |
| work_keys_str_mv | AT kenichimiyamoto dispositionkineticsoftaxanesinperitonealdissemination AT tsutomushimada dispositionkineticsoftaxanesinperitonealdissemination AT kazukisawamoto dispositionkineticsoftaxanesinperitonealdissemination AT yoshimichisai dispositionkineticsoftaxanesinperitonealdissemination AT yutakayonemura dispositionkineticsoftaxanesinperitonealdissemination |