Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade
Abstract Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer’s disease and neurodegeneration. Here, we examine its associations with up to over a decade-long changes in brain atrophy and microstru...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55009-z |
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| author | Qu Tian Erin E. Greig Christos Davatzikos Bennett A. Landman Susan M. Resnick Luigi Ferrucci |
| author_facet | Qu Tian Erin E. Greig Christos Davatzikos Bennett A. Landman Susan M. Resnick Luigi Ferrucci |
| author_sort | Qu Tian |
| collection | DOAJ |
| description | Abstract Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer’s disease and neurodegeneration. Here, we examine its associations with up to over a decade-long changes in brain atrophy and microstructure. Higher in vivo skeletal muscle oxidative capacity via MR spectroscopy (post-exercise recovery rate, kPCr) is associated with less ventricular enlargement and brain aging progression, and less atrophy in specific regions, notably primary sensorimotor cortex, temporal white and gray matter, thalamus, occipital areas, cingulate cortex, and cerebellum white matter. Higher kPCr is also associated with less microstructural integrity decline in white matter around cingulate, including superior longitudinal fasciculus, corpus callosum, and cingulum. Higher in vivo muscle oxidative capacity is associated with preserved brain structure up to over a decade, particularly in areas important for cognition, motor function, and sensorimotor integration. |
| format | Article |
| id | doaj-art-fb8b67430211404bbee03ab7fb1e99f0 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-fb8b67430211404bbee03ab7fb1e99f02025-01-05T12:36:04ZengNature PortfolioNature Communications2041-17232024-12-0115111210.1038/s41467-024-55009-zHigher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decadeQu Tian0Erin E. Greig1Christos Davatzikos2Bennett A. Landman3Susan M. Resnick4Luigi Ferrucci5Longitudinal Studies Section, Translational Gerontology Branch, National Institute on AgingLongitudinal Studies Section, Translational Gerontology Branch, National Institute on AgingRadiology Department, Perelman School of Medicine, University of PennsylvaniaDepartment of Computer Science, Vanderbilt UniversityBrain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on AgingLongitudinal Studies Section, Translational Gerontology Branch, National Institute on AgingAbstract Impaired muscle mitochondrial oxidative capacity is associated with future cognitive impairment, and higher levels of PET and blood biomarkers of Alzheimer’s disease and neurodegeneration. Here, we examine its associations with up to over a decade-long changes in brain atrophy and microstructure. Higher in vivo skeletal muscle oxidative capacity via MR spectroscopy (post-exercise recovery rate, kPCr) is associated with less ventricular enlargement and brain aging progression, and less atrophy in specific regions, notably primary sensorimotor cortex, temporal white and gray matter, thalamus, occipital areas, cingulate cortex, and cerebellum white matter. Higher kPCr is also associated with less microstructural integrity decline in white matter around cingulate, including superior longitudinal fasciculus, corpus callosum, and cingulum. Higher in vivo muscle oxidative capacity is associated with preserved brain structure up to over a decade, particularly in areas important for cognition, motor function, and sensorimotor integration.https://doi.org/10.1038/s41467-024-55009-z |
| spellingShingle | Qu Tian Erin E. Greig Christos Davatzikos Bennett A. Landman Susan M. Resnick Luigi Ferrucci Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade Nature Communications |
| title | Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade |
| title_full | Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade |
| title_fullStr | Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade |
| title_full_unstemmed | Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade |
| title_short | Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade |
| title_sort | higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade |
| url | https://doi.org/10.1038/s41467-024-55009-z |
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