IGFBP1 orchestrates metabolic reprogramming to drive clear cell renal cell carcinoma progression through NR1H4-mediated lipid homeostasis disruption

IGFBP1 orchestrates metabolic reprogramming to drive clear cell renal cell carcinoma progression through NR1H4-mediated lipid homeostasis disruption

Abstract The hallmark lipid accumulation phenotype observed in clear cell renal cell carcinoma (ccRCC) serves as a critical pathophysiological driver of tumor progression. Our investigation revealed that IGFBP1 expression was significantly elevated in ccRCC versus matched normal renal tissues, with...

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Bibliographic Details
Main Authors: Yanning Sun, Yuhu Hao, Fan Peng, Hongju Ling, Kai Sun, Jiechuan Qiu, Tianmin Yang, Leizuo Zhao, Qinghua Xia
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
ccRCC
IGFBP1
NR1H4
Lipid metabolism
Endoplasmic reticulum stress
Online Access:https://doi.org/10.1186/s12935-025-03904-w
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https://doi.org/10.1186/s12935-025-03904-w

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