Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis
Background: Autoimmune polyglandular syndrome type 3 (APS-3) encompasses autoimmune thyroid disease and other autoimmune disorders. APS-3 is further categorized into four subtypes, with APS-3B involving gastrointestinal autoimmune diseases. In this case, we diagnosed autoimmune gastritis, a conditio...
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SMC MEDIA SRL
2025-05-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5376 |
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| author | Sayaka Mabuchi Hiroya Mabuchi Takashi Watari |
| author_facet | Sayaka Mabuchi Hiroya Mabuchi Takashi Watari |
| author_sort | Sayaka Mabuchi |
| collection | DOAJ |
| description | Background: Autoimmune polyglandular syndrome type 3 (APS-3) encompasses autoimmune thyroid disease and other autoimmune disorders. APS-3 is further categorized into four subtypes, with APS-3B involving gastrointestinal autoimmune diseases. In this case, we diagnosed autoimmune gastritis, a condition challenging to identify based on endoscopic findings alone, and asymptomatic primary biliary cholangitis (PBC) through the recognition of APS-3B.
Case report: An 84-year-old female patient presented with forgetfulness and a history of Hashimoto’s disease. Although endoscopy revealed pan-atrophic gastritis, autoimmune gastritis was suspected rather than Helicobacter pylori infection due to consideration of the APS-3 framework. Specific observations, including adherent mucus and remnants of oxyntic mucosa, guided tests for anti-endogenous antibodies, confirming autoimmune gastritis. Recognizing APS-3B prompted further evaluation for PBC, including measurement of anti-mitochondrial M2 antibody, which led to the diagnosis of asymptomatic PBC.
Conclusion: Recognition of APS-3 offers a valuable framework for the differential diagnosis of autoimmune diseases. |
| format | Article |
| id | doaj-art-fb83623fdb1c448e98c923804aa19df1 |
| institution | DOAJ |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-fb83623fdb1c448e98c923804aa19df12025-08-20T03:07:37ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-05-0110.12890/2025_0053764911Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitisSayaka Mabuchi0Hiroya Mabuchi1Takashi Watari2Department of General Medicine, Iinan Hospital, Shimane, JapanDepartment of General Medicine, Iinan Hospital, Shimane, JapanIntegrated Clinical Education Center, Kyoto University Hospital, Kyoto, Japan; General Medicine Center, Shimane University Hospital, Shimane, JapanBackground: Autoimmune polyglandular syndrome type 3 (APS-3) encompasses autoimmune thyroid disease and other autoimmune disorders. APS-3 is further categorized into four subtypes, with APS-3B involving gastrointestinal autoimmune diseases. In this case, we diagnosed autoimmune gastritis, a condition challenging to identify based on endoscopic findings alone, and asymptomatic primary biliary cholangitis (PBC) through the recognition of APS-3B. Case report: An 84-year-old female patient presented with forgetfulness and a history of Hashimoto’s disease. Although endoscopy revealed pan-atrophic gastritis, autoimmune gastritis was suspected rather than Helicobacter pylori infection due to consideration of the APS-3 framework. Specific observations, including adherent mucus and remnants of oxyntic mucosa, guided tests for anti-endogenous antibodies, confirming autoimmune gastritis. Recognizing APS-3B prompted further evaluation for PBC, including measurement of anti-mitochondrial M2 antibody, which led to the diagnosis of asymptomatic PBC. Conclusion: Recognition of APS-3 offers a valuable framework for the differential diagnosis of autoimmune diseases.https://www.ejcrim.com/index.php/EJCRIM/article/view/5376autoimmune polyglandular syndrome type 3diagnosisautoimmune gastritisprimary biliary cholangitis |
| spellingShingle | Sayaka Mabuchi Hiroya Mabuchi Takashi Watari Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis European Journal of Case Reports in Internal Medicine autoimmune polyglandular syndrome type 3 diagnosis autoimmune gastritis primary biliary cholangitis |
| title | Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis |
| title_full | Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis |
| title_fullStr | Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis |
| title_full_unstemmed | Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis |
| title_short | Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis |
| title_sort | autoimmune polyglandular syndrome type 3b a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis |
| topic | autoimmune polyglandular syndrome type 3 diagnosis autoimmune gastritis primary biliary cholangitis |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5376 |
| work_keys_str_mv | AT sayakamabuchi autoimmunepolyglandularsyndrometype3bakeytodiagnosingautoimmunegastritisandasymptomaticprimarybiliarycholangitis AT hiroyamabuchi autoimmunepolyglandularsyndrometype3bakeytodiagnosingautoimmunegastritisandasymptomaticprimarybiliarycholangitis AT takashiwatari autoimmunepolyglandularsyndrometype3bakeytodiagnosingautoimmunegastritisandasymptomaticprimarybiliarycholangitis |