422 Preclinical drug screen leads to clinical trial for treatment of hypoglycemia unawareness in type 1 diabetes mellitus

Objectives/Goals: People with insulin-treated diabetes face hypoglycemia risk due to imperfect insulin replacement and impaired counterregulation. We identified the dopamine antagonist, metoclopramide, as a potential treatment. Hypothesis: Treatment with metoclopramide will prevent the development o...

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Main Authors: Micah Devore, Ashley N. Iles, Lily A. Schoeder, Megan B. Music, Bansi V. Patel, Ashlee R. Marksbury, Mason M. Wooten, Andrea M. Woodcox, Zachary Beckner, Erica L. Macon, Simon J. Fisher
Format: Article
Language:English
Published: Cambridge University Press 2025-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S205986612401029X/type/journal_article
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