ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMES
Analysis of whole-genome sequences often leads to problems of large dimensionality where the number of parameters exceeds the number of available observations. We offer methodology of genome-wide association study and investigate various approaches to assess contribution of mutations in the emergenc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
National Academy of Sciences of Belarus, the United Institute of Informatics Problems
2016-10-01
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| Series: | Informatika |
| Online Access: | https://inf.grid.by/jour/article/view/126 |
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| _version_ | 1849336242356879360 |
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| author | R. S. Sergeev I. S. Kavaliou A. V. Tuzikov A. Rosenthal A. Gabrielian |
| author_facet | R. S. Sergeev I. S. Kavaliou A. V. Tuzikov A. Rosenthal A. Gabrielian |
| author_sort | R. S. Sergeev |
| collection | DOAJ |
| description | Analysis of whole-genome sequences often leads to problems of large dimensionality where the number of parameters exceeds the number of available observations. We offer methodology of genome-wide association study and investigate various approaches to assess contribution of mutations in the emergence and development of drug resistance in Mycobacterium tuberculosis. We present the results of our experiments aimed at identifying resistance mutations to the major anti- TB drugs based on data obtained from patients in Belarus. |
| format | Article |
| id | doaj-art-fb80b2e3ccd4449fb9978caa424517c0 |
| institution | Kabale University |
| issn | 1816-0301 |
| language | Russian |
| publishDate | 2016-10-01 |
| publisher | National Academy of Sciences of Belarus, the United Institute of Informatics Problems |
| record_format | Article |
| series | Informatika |
| spelling | doaj-art-fb80b2e3ccd4449fb9978caa424517c02025-08-20T03:45:02ZrusNational Academy of Sciences of Belarus, the United Institute of Informatics ProblemsInformatika1816-03012016-10-01017591125ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMESR. S. Sergeev0I. S. Kavaliou1A. V. Tuzikov2A. Rosenthal3A. Gabrielian4Объединенный институт проблем информатики НАН БеларусиEPAM SystemsОбъединенный институт проблем информатики НАН БеларусиOffice of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious DiseasesOffice of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious DiseasesAnalysis of whole-genome sequences often leads to problems of large dimensionality where the number of parameters exceeds the number of available observations. We offer methodology of genome-wide association study and investigate various approaches to assess contribution of mutations in the emergence and development of drug resistance in Mycobacterium tuberculosis. We present the results of our experiments aimed at identifying resistance mutations to the major anti- TB drugs based on data obtained from patients in Belarus.https://inf.grid.by/jour/article/view/126 |
| spellingShingle | R. S. Sergeev I. S. Kavaliou A. V. Tuzikov A. Rosenthal A. Gabrielian ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMES Informatika |
| title | ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMES |
| title_full | ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMES |
| title_fullStr | ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMES |
| title_full_unstemmed | ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMES |
| title_short | ALGORITHMS FOR IDENTIFYING DRUG-RESISTANCE MUTATIONS IN M. TUBERCULOSIS GENOMES |
| title_sort | algorithms for identifying drug resistance mutations in m tuberculosis genomes |
| url | https://inf.grid.by/jour/article/view/126 |
| work_keys_str_mv | AT rssergeev algorithmsforidentifyingdrugresistancemutationsinmtuberculosisgenomes AT iskavaliou algorithmsforidentifyingdrugresistancemutationsinmtuberculosisgenomes AT avtuzikov algorithmsforidentifyingdrugresistancemutationsinmtuberculosisgenomes AT arosenthal algorithmsforidentifyingdrugresistancemutationsinmtuberculosisgenomes AT agabrielian algorithmsforidentifyingdrugresistancemutationsinmtuberculosisgenomes |