Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes
The study objective was to assess chosen biochemical parameters of blood and bioelectric function of the retina in patients with T1DM. The study group consisted of 41 patients with T1DM with no signs of diabetic retinopathy. The control group included 21 pediatric patients. We performed (1) S-cone E...
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/274726 |
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| author | Kornel Semeran Przemysław Pawłowski Łukasz Lisowski Izabela Szczepaniak Jerzy Wójtowicz Sławomir Ławicki Alina Bakunowicz-Łazarczyk Artur Bossowski |
| author_facet | Kornel Semeran Przemysław Pawłowski Łukasz Lisowski Izabela Szczepaniak Jerzy Wójtowicz Sławomir Ławicki Alina Bakunowicz-Łazarczyk Artur Bossowski |
| author_sort | Kornel Semeran |
| collection | DOAJ |
| description | The study objective was to assess chosen biochemical parameters of blood and bioelectric function of the retina in patients with T1DM. The study group consisted of 41 patients with T1DM with no signs of diabetic retinopathy. The control group included 21 pediatric patients. We performed (1) S-cone ERG testing with retina response stimulation in both eyes at the luminance of 0.1, 0.2, and 0.5 (cd × s/m2) with the 440 nm blue flash and light application of the amber background (300 ph cd/m2, 495 nm wavelength), (2) anthropometric measurements, (3) biochemical investigations: IL-17, VEGF, and ADM by the ELISA method. A comparison of the ERG results with biochemical investigations indicates a likely correlation between the worsening of retinal bioelectric function and VEGF levels growing with diabetes duration. We showed a negative correlation between ADM and HbA1c and described possible causes of ADM reduction observed in subgroup I. We demonstrated the presence of bioelectric retinal dysfunction already before the diagnosis of diabetic retinopathy, which provides new possibilities in the diagnosis of preclinical chronic complications of diabetes. The changes observed in the levels of IL-17, ADM, and VEGF suggest their involvement in the diabetic pathogenesis of eye diseases. |
| format | Article |
| id | doaj-art-fb7de2c7021144d2b5e25d1aaf9ea800 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fb7de2c7021144d2b5e25d1aaf9ea8002025-08-20T03:25:57ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/274726274726Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of DiabetesKornel Semeran0Przemysław Pawłowski1Łukasz Lisowski2Izabela Szczepaniak3Jerzy Wójtowicz4Sławomir Ławicki5Alina Bakunowicz-Łazarczyk6Artur Bossowski7Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Ulica Waszyngtona 17, 15-274 Białystok, PolandDepartment of Pediatrics Ophthalmology with Strabismus Treatment Unit, Medical University of Białystok, Ulica Waszyngtona 17, 15-274 Białystok, PolandScientific Circle at the Department of Pediatric Ophthalmology with Strabismus Treatment Unit, Medical University of Białystok, Ulica Waszyngtona 17, 15-274 Białystok, PolandDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Ulica Waszyngtona 17, 15-274 Białystok, PolandDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Ulica Waszyngtona 17, 15-274 Białystok, PolandDepartment of Biochemical Diagnostics, Medical University of Białystok, Ulica Waszyngtona 15A, 15-269 Białystok, PolandDepartment of Pediatrics Ophthalmology with Strabismus Treatment Unit, Medical University of Białystok, Ulica Waszyngtona 17, 15-274 Białystok, PolandDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Białystok, Ulica Waszyngtona 17, 15-274 Białystok, PolandThe study objective was to assess chosen biochemical parameters of blood and bioelectric function of the retina in patients with T1DM. The study group consisted of 41 patients with T1DM with no signs of diabetic retinopathy. The control group included 21 pediatric patients. We performed (1) S-cone ERG testing with retina response stimulation in both eyes at the luminance of 0.1, 0.2, and 0.5 (cd × s/m2) with the 440 nm blue flash and light application of the amber background (300 ph cd/m2, 495 nm wavelength), (2) anthropometric measurements, (3) biochemical investigations: IL-17, VEGF, and ADM by the ELISA method. A comparison of the ERG results with biochemical investigations indicates a likely correlation between the worsening of retinal bioelectric function and VEGF levels growing with diabetes duration. We showed a negative correlation between ADM and HbA1c and described possible causes of ADM reduction observed in subgroup I. We demonstrated the presence of bioelectric retinal dysfunction already before the diagnosis of diabetic retinopathy, which provides new possibilities in the diagnosis of preclinical chronic complications of diabetes. The changes observed in the levels of IL-17, ADM, and VEGF suggest their involvement in the diabetic pathogenesis of eye diseases.http://dx.doi.org/10.1155/2013/274726 |
| spellingShingle | Kornel Semeran Przemysław Pawłowski Łukasz Lisowski Izabela Szczepaniak Jerzy Wójtowicz Sławomir Ławicki Alina Bakunowicz-Łazarczyk Artur Bossowski Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes Mediators of Inflammation |
| title | Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes |
| title_full | Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes |
| title_fullStr | Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes |
| title_full_unstemmed | Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes |
| title_short | Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes |
| title_sort | plasma levels of il 17 vegf and adrenomedullin and s cone dysfunction of the retina in children and adolescents without signs of retinopathy and with varied duration of diabetes |
| url | http://dx.doi.org/10.1155/2013/274726 |
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