Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers
About 50% of malaria infections in India are attributed to Plasmodium falciparum but relatively little is known about the genetic structure of the parasite populations. The molecular genotyping of the parasite populations by merozoite surface protein (msp1 and msp2) and glutamate-rich protein (glurp...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/140867 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849468086413950976 |
|---|---|
| author | Purva Gupta Ruchi Singh Haris Khan Adil Raza Veena Yadavendu R. M. Bhatt Vineeta Singh |
| author_facet | Purva Gupta Ruchi Singh Haris Khan Adil Raza Veena Yadavendu R. M. Bhatt Vineeta Singh |
| author_sort | Purva Gupta |
| collection | DOAJ |
| description | About 50% of malaria infections in India are attributed to Plasmodium falciparum but relatively little is known about the genetic structure of the parasite populations. The molecular genotyping of the parasite populations by merozoite surface protein (msp1 and msp2) and glutamate-rich protein (glurp) genes identifies the existing parasite population in the regions which help in understanding the molecular mechanisms involved in the parasite’s drive for survival. This study reveals the genetic profile of the parasite population in selected regions across the country with varying degree of endemicity among them. We also report the prevalence of Pfcrt mutations in this parasite population to evaluate the pattern of drug resistance development in them. |
| format | Article |
| id | doaj-art-fb7c5fd8280f4f3f8be0edca2a8d7394 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-fb7c5fd8280f4f3f8be0edca2a8d73942025-08-20T03:25:57ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/140867140867Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular MarkersPurva Gupta0Ruchi Singh1Haris Khan2Adil Raza3Veena Yadavendu4R. M. Bhatt5Vineeta Singh6National Institute of Malaria Research (ICMR), Sector 8, Dwarka, New Delhi 110077, IndiaNational Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi 110029, IndiaAligarh Muslim University, Aligarh, IndiaAligarh Muslim University, Aligarh, IndiaNational Institute of Malaria Research (ICMR), Sector 8, Dwarka, New Delhi 110077, IndiaNational Institute of Malaria Research (ICMR), Sector 8, Dwarka, New Delhi 110077, IndiaNational Institute of Malaria Research (ICMR), Sector 8, Dwarka, New Delhi 110077, IndiaAbout 50% of malaria infections in India are attributed to Plasmodium falciparum but relatively little is known about the genetic structure of the parasite populations. The molecular genotyping of the parasite populations by merozoite surface protein (msp1 and msp2) and glutamate-rich protein (glurp) genes identifies the existing parasite population in the regions which help in understanding the molecular mechanisms involved in the parasite’s drive for survival. This study reveals the genetic profile of the parasite population in selected regions across the country with varying degree of endemicity among them. We also report the prevalence of Pfcrt mutations in this parasite population to evaluate the pattern of drug resistance development in them.http://dx.doi.org/10.1155/2014/140867 |
| spellingShingle | Purva Gupta Ruchi Singh Haris Khan Adil Raza Veena Yadavendu R. M. Bhatt Vineeta Singh Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers The Scientific World Journal |
| title | Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers |
| title_full | Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers |
| title_fullStr | Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers |
| title_full_unstemmed | Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers |
| title_short | Genetic Profiling of the Plasmodium falciparum Population Using Antigenic Molecular Markers |
| title_sort | genetic profiling of the plasmodium falciparum population using antigenic molecular markers |
| url | http://dx.doi.org/10.1155/2014/140867 |
| work_keys_str_mv | AT purvagupta geneticprofilingoftheplasmodiumfalciparumpopulationusingantigenicmolecularmarkers AT ruchisingh geneticprofilingoftheplasmodiumfalciparumpopulationusingantigenicmolecularmarkers AT hariskhan geneticprofilingoftheplasmodiumfalciparumpopulationusingantigenicmolecularmarkers AT adilraza geneticprofilingoftheplasmodiumfalciparumpopulationusingantigenicmolecularmarkers AT veenayadavendu geneticprofilingoftheplasmodiumfalciparumpopulationusingantigenicmolecularmarkers AT rmbhatt geneticprofilingoftheplasmodiumfalciparumpopulationusingantigenicmolecularmarkers AT vineetasingh geneticprofilingoftheplasmodiumfalciparumpopulationusingantigenicmolecularmarkers |