Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle
Abstract As the global population trends toward aging, the number of individuals suffering from age-related debilitating diseases is increasing. With advancing age, skeletal muscle undergoes progressive oxidative stress infiltration, coupled with detrimental factors such as impaired protein synthesi...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Cellular & Molecular Biology Letters |
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| Online Access: | https://doi.org/10.1186/s11658-025-00771-1 |
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| author | Kai Wang Mailin Gan Yuhang Lei Tianci Liao Jiaxin Li Lili Niu Ye Zhao Lei Chen Yan Wang Li Zhu Linyuan Shen |
| author_facet | Kai Wang Mailin Gan Yuhang Lei Tianci Liao Jiaxin Li Lili Niu Ye Zhao Lei Chen Yan Wang Li Zhu Linyuan Shen |
| author_sort | Kai Wang |
| collection | DOAJ |
| description | Abstract As the global population trends toward aging, the number of individuals suffering from age-related debilitating diseases is increasing. With advancing age, skeletal muscle undergoes progressive oxidative stress infiltration, coupled with detrimental factors such as impaired protein synthesis and mitochondrial DNA (mtDNA) mutations, culminating in mitochondrial dysfunction. Muscle stem cells (MuSCs), essential for skeletal muscle regeneration, also experience functional decline during this process, leading to irreversible damage to muscle integrity in older adults. A critical contributing factor is the loss of mitochondrial metabolism and function in MuSCs within skeletal muscle. The mitochondrial quality control system plays a pivotal role as a modulator, counteracting aging-associated abnormalities in energy metabolism and redox imbalance. Mitochondria meet functional demands through processes such as fission, fusion, and mitophagy. The significance of mitochondrial morphology and dynamics in the mechanisms of muscle regeneration has been consistently emphasized. In this review, we provide a comprehensive summary of recent advances in understanding the mechanisms of aging-related mitochondrial dysfunction and its role in hindering skeletal muscle regeneration. Additionally, we present novel insights into therapeutic approaches for treating aging-related myopathies. Graphical Abstract |
| format | Article |
| id | doaj-art-fb7adffb432549eeb6f57cc6dfc2ef51 |
| institution | Kabale University |
| issn | 1689-1392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj-art-fb7adffb432549eeb6f57cc6dfc2ef512025-08-20T03:43:16ZengBMCCellular & Molecular Biology Letters1689-13922025-07-0130113510.1186/s11658-025-00771-1Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscleKai Wang0Mailin Gan1Yuhang Lei2Tianci Liao3Jiaxin Li4Lili Niu5Ye Zhao6Lei Chen7Yan Wang8Li Zhu9Linyuan Shen10Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityAbstract As the global population trends toward aging, the number of individuals suffering from age-related debilitating diseases is increasing. With advancing age, skeletal muscle undergoes progressive oxidative stress infiltration, coupled with detrimental factors such as impaired protein synthesis and mitochondrial DNA (mtDNA) mutations, culminating in mitochondrial dysfunction. Muscle stem cells (MuSCs), essential for skeletal muscle regeneration, also experience functional decline during this process, leading to irreversible damage to muscle integrity in older adults. A critical contributing factor is the loss of mitochondrial metabolism and function in MuSCs within skeletal muscle. The mitochondrial quality control system plays a pivotal role as a modulator, counteracting aging-associated abnormalities in energy metabolism and redox imbalance. Mitochondria meet functional demands through processes such as fission, fusion, and mitophagy. The significance of mitochondrial morphology and dynamics in the mechanisms of muscle regeneration has been consistently emphasized. In this review, we provide a comprehensive summary of recent advances in understanding the mechanisms of aging-related mitochondrial dysfunction and its role in hindering skeletal muscle regeneration. Additionally, we present novel insights into therapeutic approaches for treating aging-related myopathies. Graphical Abstracthttps://doi.org/10.1186/s11658-025-00771-1AgingMitochondrial dynamicsMitophagyOxidative stressSkeletal muscle regeneration |
| spellingShingle | Kai Wang Mailin Gan Yuhang Lei Tianci Liao Jiaxin Li Lili Niu Ye Zhao Lei Chen Yan Wang Li Zhu Linyuan Shen Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle Cellular & Molecular Biology Letters Aging Mitochondrial dynamics Mitophagy Oxidative stress Skeletal muscle regeneration |
| title | Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle |
| title_full | Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle |
| title_fullStr | Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle |
| title_full_unstemmed | Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle |
| title_short | Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle |
| title_sort | perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle |
| topic | Aging Mitochondrial dynamics Mitophagy Oxidative stress Skeletal muscle regeneration |
| url | https://doi.org/10.1186/s11658-025-00771-1 |
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