Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in Dogs
The objective of the current study was evaluating the status of blood serum biochemical parameters in poorly controlled diabetes mellitus induced after experimental total pancreatectomy in local crossbreeding dogs. The biochemical assay was taken before the surgical operation and on the last two day...
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College of Veterinary Medicine, University of Basrah, Iraq
2023-06-01
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| Series: | Basrah Journal of Veterinary Research |
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| Online Access: | https://bjvr.uobasrah.edu.iq/article_179919_7bf3521956ebafa39b9514626794e366.pdf |
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| author | Nadhim Hasan Borhan Al-Mufti. |
| author_facet | Nadhim Hasan Borhan Al-Mufti. |
| author_sort | Nadhim Hasan |
| collection | DOAJ |
| description | The objective of the current study was evaluating the status of blood serum biochemical parameters in poorly controlled diabetes mellitus induced after experimental total pancreatectomy in local crossbreeding dogs. The biochemical assay was taken before the surgical operation and on the last two days of the insulin treatment period and after termination of insulin therapy till death of animals due to ketoacidosis after detecting severe ketonuria on urinalysis by urine stripe test when insulin withdrawn. Results of estimating the various biochemical parameters revealed a significant increase in the blood serum level of liver enzymes [Alanine amino transaminase, alkaline phosphatase, and Aspartate amino transaminase], total cholesterol and potassium ions, while a significant decrease in chloride ions took place in both insulin treatment and withdrawal periods. On the other hand, significant increases in blood serum levels of triglyceride, total bilirubin, sodium ions, and blood urea nitrogen with significant decrease in total calcium was occurred in the insulin withdrawal period only. In conclusion, the first mentioned biochemical parameters might be involved in the pathogenesis of poorly controlled diabetes mellitus while the later mentioned parameters which exhibited significant changes only after cessation of insulin therapy might be involved in the pathogenesis of surgically induced diabetic ketoacidosis in dogs. |
| format | Article |
| id | doaj-art-fb76745d22d64b0ebd494e5722afe54b |
| institution | OA Journals |
| issn | 1813-8497 2410-8456 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | College of Veterinary Medicine, University of Basrah, Iraq |
| record_format | Article |
| series | Basrah Journal of Veterinary Research |
| spelling | doaj-art-fb76745d22d64b0ebd494e5722afe54b2025-08-20T02:30:55ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562023-06-01222122310.23975/bjvetr.2023.179919179919Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in DogsNadhim Hasan0Borhan Al-Mufti.1Department of Medicine& Surgery, College of Veterinary Medicine, University of Duhok-Iraq.Department of Medicine& Surgery, College of Veterinary Medicine, University of Duhok-Iraq.The objective of the current study was evaluating the status of blood serum biochemical parameters in poorly controlled diabetes mellitus induced after experimental total pancreatectomy in local crossbreeding dogs. The biochemical assay was taken before the surgical operation and on the last two days of the insulin treatment period and after termination of insulin therapy till death of animals due to ketoacidosis after detecting severe ketonuria on urinalysis by urine stripe test when insulin withdrawn. Results of estimating the various biochemical parameters revealed a significant increase in the blood serum level of liver enzymes [Alanine amino transaminase, alkaline phosphatase, and Aspartate amino transaminase], total cholesterol and potassium ions, while a significant decrease in chloride ions took place in both insulin treatment and withdrawal periods. On the other hand, significant increases in blood serum levels of triglyceride, total bilirubin, sodium ions, and blood urea nitrogen with significant decrease in total calcium was occurred in the insulin withdrawal period only. In conclusion, the first mentioned biochemical parameters might be involved in the pathogenesis of poorly controlled diabetes mellitus while the later mentioned parameters which exhibited significant changes only after cessation of insulin therapy might be involved in the pathogenesis of surgically induced diabetic ketoacidosis in dogs.https://bjvr.uobasrah.edu.iq/article_179919_7bf3521956ebafa39b9514626794e366.pdfdiabetespancreatectomyparametersketoacidosis |
| spellingShingle | Nadhim Hasan Borhan Al-Mufti. Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in Dogs Basrah Journal of Veterinary Research diabetes pancreatectomy parameters ketoacidosis |
| title | Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in Dogs |
| title_full | Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in Dogs |
| title_fullStr | Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in Dogs |
| title_full_unstemmed | Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in Dogs |
| title_short | Biochemical Study of Induced Diabetes Mellitus by Experimental Total Pancreatectomy in Dogs |
| title_sort | biochemical study of induced diabetes mellitus by experimental total pancreatectomy in dogs |
| topic | diabetes pancreatectomy parameters ketoacidosis |
| url | https://bjvr.uobasrah.edu.iq/article_179919_7bf3521956ebafa39b9514626794e366.pdf |
| work_keys_str_mv | AT nadhimhasan biochemicalstudyofinduceddiabetesmellitusbyexperimentaltotalpancreatectomyindogs AT borhanalmufti biochemicalstudyofinduceddiabetesmellitusbyexperimentaltotalpancreatectomyindogs |