Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols
Non-noble metals catalyzed carbonylative reactions serve as straightforward and sustainable methods for the synthesis of functionalized carbonyl-containing compounds. Herein, a low-valent-tungsten-catalyzed reaction that enables the coupling of aryl iodides and alcohols or phenols was disclosed, emp...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/22/5305 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850266527110004736 |
|---|---|
| author | Feihua Ye Lin Lu Zhaoyang Huang Yunwei Huang Lixuan Huang Chunsheng Li Xiang Li |
| author_facet | Feihua Ye Lin Lu Zhaoyang Huang Yunwei Huang Lixuan Huang Chunsheng Li Xiang Li |
| author_sort | Feihua Ye |
| collection | DOAJ |
| description | Non-noble metals catalyzed carbonylative reactions serve as straightforward and sustainable methods for the synthesis of functionalized carbonyl-containing compounds. Herein, a low-valent-tungsten-catalyzed reaction that enables the coupling of aryl iodides and alcohols or phenols was disclosed, employing the readily available W(CO)<sub>6</sub> as the effective catalyst and PPh<sub>3</sub> as ligand. Under the optimal reaction conditions, aryl iodides smoothly underwent carbonylative coupling reactions with alcohols or phenols, processing the feature of broad substrate scope and good functional groups tolerance. Furthermore, this conversion can be carried out on a gram scale, showcasing significant promise in the synthesis of pharmaceutical or biologically active compounds. |
| format | Article |
| id | doaj-art-fb745ffe0af9449088acb7252a2801dd |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-fb745ffe0af9449088acb7252a2801dd2025-08-20T01:54:08ZengMDPI AGMolecules1420-30492024-11-012922530510.3390/molecules29225305Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and AlcoholsFeihua Ye0Lin Lu1Zhaoyang Huang2Yunwei Huang3Lixuan Huang4Chunsheng Li5Xiang Li6School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, ChinaSchool of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, ChinaSchool of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, ChinaSchool of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, ChinaSchool of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, ChinaSchool of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, ChinaSchool of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing 526061, ChinaNon-noble metals catalyzed carbonylative reactions serve as straightforward and sustainable methods for the synthesis of functionalized carbonyl-containing compounds. Herein, a low-valent-tungsten-catalyzed reaction that enables the coupling of aryl iodides and alcohols or phenols was disclosed, employing the readily available W(CO)<sub>6</sub> as the effective catalyst and PPh<sub>3</sub> as ligand. Under the optimal reaction conditions, aryl iodides smoothly underwent carbonylative coupling reactions with alcohols or phenols, processing the feature of broad substrate scope and good functional groups tolerance. Furthermore, this conversion can be carried out on a gram scale, showcasing significant promise in the synthesis of pharmaceutical or biologically active compounds.https://www.mdpi.com/1420-3049/29/22/5305tungsten catalystcarbonylationbenzoatesoxidative additionsynthetic method |
| spellingShingle | Feihua Ye Lin Lu Zhaoyang Huang Yunwei Huang Lixuan Huang Chunsheng Li Xiang Li Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols Molecules tungsten catalyst carbonylation benzoates oxidative addition synthetic method |
| title | Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols |
| title_full | Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols |
| title_fullStr | Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols |
| title_full_unstemmed | Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols |
| title_short | Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols |
| title_sort | low valent tungsten catalyzed carbonylative synthesis of benzoates from aryl iodides and alcohols |
| topic | tungsten catalyst carbonylation benzoates oxidative addition synthetic method |
| url | https://www.mdpi.com/1420-3049/29/22/5305 |
| work_keys_str_mv | AT feihuaye lowvalenttungstencatalyzedcarbonylativesynthesisofbenzoatesfromaryliodidesandalcohols AT linlu lowvalenttungstencatalyzedcarbonylativesynthesisofbenzoatesfromaryliodidesandalcohols AT zhaoyanghuang lowvalenttungstencatalyzedcarbonylativesynthesisofbenzoatesfromaryliodidesandalcohols AT yunweihuang lowvalenttungstencatalyzedcarbonylativesynthesisofbenzoatesfromaryliodidesandalcohols AT lixuanhuang lowvalenttungstencatalyzedcarbonylativesynthesisofbenzoatesfromaryliodidesandalcohols AT chunshengli lowvalenttungstencatalyzedcarbonylativesynthesisofbenzoatesfromaryliodidesandalcohols AT xiangli lowvalenttungstencatalyzedcarbonylativesynthesisofbenzoatesfromaryliodidesandalcohols |