Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imaging
Objectives Most functional magnetic resonance research has primarily examined alterations in the affected kidney, often neglecting the contralateral kidney. Our study aims to investigate whether imaging parameters accurately depict changes in both the renal cortex and medulla in a unilateral uretera...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2359642 |
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| author | Lingtao Zhang Xukai Mo Zijie Jiang Wenfeng Mai Haiwei Su Zhihua Zhang Kunlin Ye Dandan Fu Shuangquan Zhao Changzheng Shi |
| author_facet | Lingtao Zhang Xukai Mo Zijie Jiang Wenfeng Mai Haiwei Su Zhihua Zhang Kunlin Ye Dandan Fu Shuangquan Zhao Changzheng Shi |
| author_sort | Lingtao Zhang |
| collection | DOAJ |
| description | Objectives Most functional magnetic resonance research has primarily examined alterations in the affected kidney, often neglecting the contralateral kidney. Our study aims to investigate whether imaging parameters accurately depict changes in both the renal cortex and medulla in a unilateral ureteral obstruction rat model, thereby showcasing the utility of intravoxel incoherent motion (IVIM) in evaluating contralateral renal changes.Methods Six rats underwent MR scans and were subsequently sacrificed for baseline histological examination. Following the induction of left ureteral obstruction, 48 rats were scanned, and the histopathological examinations were conducted on days 3, 7, 10, 14, 21, 28, 35, and 42. The apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudodiffusion (D*), and perfusion fraction (f) values were measured using IVIM.Results On the 10th day of obstruction, both cortical and medullary ADC values differed significantly between the UUO10 group and the sham group (p < 0.01). The cortical D values showed statistically significant differences between UUO3 group and sham group (p < 0.01) but not among UUO groups at other time point. Additionally, the cortical and medullary f values were statistically significant between the UUO21 group and the sham group (p < 0.01). Especially, the cortical f values exhibited significant differences between the UUO21 group and the UUO groups with shorter obstruction time (at time point of 3, 7, 10, 14 day) (p < 0.01).Conclusions Significant hemodynamic alterations were observed in the contralateral kidney following renal obstruction. IVIM accurately captures changes in the unobstructed kidney. Particularly, the cortical f value exhibits the highest potential for assessing contralateral renal modifications. |
| format | Article |
| id | doaj-art-fb7220e6435841bead0a0e1159a3f512 |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-fb7220e6435841bead0a0e1159a3f5122025-08-20T02:29:56ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2359642Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imagingLingtao Zhang0Xukai Mo1Zijie Jiang2Wenfeng Mai3Haiwei Su4Zhihua Zhang5Kunlin Ye6Dandan Fu7Shuangquan Zhao8Changzheng Shi9Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Medical Imaging Center, The Shenzhen Hospital of Southern Medical University, Shenzhen, ChinaMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Pediatric Surgery, Huizhou Central People’s Hospital, Huizhou, ChinaMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaMedical Imaging Center, The Fifth Affiliated Hospital of Jinan University, Heyuan, ChinaMedical Imaging Center, The Second Affiliated Hospital of Shenzhen University, Shenzhen, ChinaMedical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaObjectives Most functional magnetic resonance research has primarily examined alterations in the affected kidney, often neglecting the contralateral kidney. Our study aims to investigate whether imaging parameters accurately depict changes in both the renal cortex and medulla in a unilateral ureteral obstruction rat model, thereby showcasing the utility of intravoxel incoherent motion (IVIM) in evaluating contralateral renal changes.Methods Six rats underwent MR scans and were subsequently sacrificed for baseline histological examination. Following the induction of left ureteral obstruction, 48 rats were scanned, and the histopathological examinations were conducted on days 3, 7, 10, 14, 21, 28, 35, and 42. The apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudodiffusion (D*), and perfusion fraction (f) values were measured using IVIM.Results On the 10th day of obstruction, both cortical and medullary ADC values differed significantly between the UUO10 group and the sham group (p < 0.01). The cortical D values showed statistically significant differences between UUO3 group and sham group (p < 0.01) but not among UUO groups at other time point. Additionally, the cortical and medullary f values were statistically significant between the UUO21 group and the sham group (p < 0.01). Especially, the cortical f values exhibited significant differences between the UUO21 group and the UUO groups with shorter obstruction time (at time point of 3, 7, 10, 14 day) (p < 0.01).Conclusions Significant hemodynamic alterations were observed in the contralateral kidney following renal obstruction. IVIM accurately captures changes in the unobstructed kidney. Particularly, the cortical f value exhibits the highest potential for assessing contralateral renal modifications.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2359642fMRIkidneyIVIMpathophysiology |
| spellingShingle | Lingtao Zhang Xukai Mo Zijie Jiang Wenfeng Mai Haiwei Su Zhihua Zhang Kunlin Ye Dandan Fu Shuangquan Zhao Changzheng Shi Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imaging Renal Failure fMRI kidney IVIM pathophysiology |
| title | Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imaging |
| title_full | Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imaging |
| title_fullStr | Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imaging |
| title_full_unstemmed | Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imaging |
| title_short | Contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion-weighted imaging |
| title_sort | contralateral renal change in a unilateral ureteral obstruction rat model using intravoxel incoherent motion diffusion weighted imaging |
| topic | fMRI kidney IVIM pathophysiology |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2359642 |
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