Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associate...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/8261432 |
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| _version_ | 1832547474608226304 |
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| author | Alex S. Yamashita Thiago Belchior Fábio S. Lira Nicolette C. Bishop Barbara Wessner José C. Rosa William T. Festuccia |
| author_facet | Alex S. Yamashita Thiago Belchior Fábio S. Lira Nicolette C. Bishop Barbara Wessner José C. Rosa William T. Festuccia |
| author_sort | Alex S. Yamashita |
| collection | DOAJ |
| description | Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β-cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation. |
| format | Article |
| id | doaj-art-fb6ab7ed404245669435a01830ef71b9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fb6ab7ed404245669435a01830ef71b92025-02-03T06:44:38ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/82614328261432Regulation of Metabolic Disease-Associated Inflammation by Nutrient SensorsAlex S. Yamashita0Thiago Belchior1Fábio S. Lira2Nicolette C. Bishop3Barbara Wessner4José C. Rosa5William T. Festuccia6Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508000 Sao Paulo-SP, BrazilDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508000 Sao Paulo-SP, BrazilExercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), 19060-900 Presidente Prudente-SP, BrazilSchool of Sports, Exercise and Health Science, Loughborough University, Loughborough, UKCentre for Sport Science and University Sports, Vienna, AustriaDepartment of Cell Biology and Development, Institute of Biomedical Sciences, University of Sao Paulo, 05508000 Sao Paulo-SP, BrazilDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508000 Sao Paulo-SP, BrazilVisceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β-cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation.http://dx.doi.org/10.1155/2018/8261432 |
| spellingShingle | Alex S. Yamashita Thiago Belchior Fábio S. Lira Nicolette C. Bishop Barbara Wessner José C. Rosa William T. Festuccia Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors Mediators of Inflammation |
| title | Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors |
| title_full | Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors |
| title_fullStr | Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors |
| title_full_unstemmed | Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors |
| title_short | Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors |
| title_sort | regulation of metabolic disease associated inflammation by nutrient sensors |
| url | http://dx.doi.org/10.1155/2018/8261432 |
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