Direct high-throughput deconvolution of non-canonical bases via nanopore sequencing and bootstrapped learning

Direct high-throughput deconvolution of non-canonical bases via nanopore sequencing and bootstrapped learning

Abstract The discovery of non-canonical bases (NCBs) and development of synthetic xeno-nucleic acids (XNAs) has spawned interest in many applications in viral genomics, synthetic biology and DNA storage. However, inability to do high-throughput sequencing of NCBs has been a significant limitation. W...

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Main Authors: Mauricio Perez, Michiko Kimoto, Priscilla Rajakumar, Chayaporn Suphavilai, Rafael Peres da Silva, Hui Pen Tan, Nicholas Ting Xun Ong, Hannah Nicholas, Ichiro Hirao, Wei Leong Chew, Niranjan Nagarajan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62347-z
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