CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres in equids

CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres in equids

Abstract Background While CENP-A is the epigenetic determinant of the centromeric function, the role of CENP-B, a centromeric protein binding a specific DNA sequence, the CENP-B-box, remains elusive. In the few mammalian species analyzed so far, the CENP-B box is contained in the major satellite rep...

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Bibliographic Details
Main Authors: Eleonora Cappelletti, Francesca M. Piras, Marialaura Biundo, Elena Raimondi, Solomon G. Nergadze, Elena Giulotto
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Genome Biology
Subjects:
CENP-B
Centromere
Satellite DNA
Karyotype evolution
Genus Equus
Online Access:https://doi.org/10.1186/s13059-025-03490-0
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