Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome
Background: COVID-19 is a highly contagious disease that has already affected millions of people worldwide. Proinflammatory cytokines in COVID-19 infection change lipid metabolism and profile. This study investigates the association between lipid profile and inflammatory markers with the severity an...
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| Format: | Article |
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Mazandaran University of Medical Sciences and Health Services
2022-11-01
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| Series: | Research in Molecular Medicine |
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| Online Access: | http://rmm.mazums.ac.ir/article-1-507-en.pdf |
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| author | Amirhossein Khoshgoeian Adele Bahar Zahra Kashi Mina Khasayesi Shima Yahoo Torghabe Mahmood Moosazadeh Zahra Hosseini-khah |
| author_facet | Amirhossein Khoshgoeian Adele Bahar Zahra Kashi Mina Khasayesi Shima Yahoo Torghabe Mahmood Moosazadeh Zahra Hosseini-khah |
| author_sort | Amirhossein Khoshgoeian |
| collection | DOAJ |
| description | Background: COVID-19 is a highly contagious disease that has already affected millions of people worldwide. Proinflammatory cytokines in COVID-19 infection change lipid metabolism and profile. This study investigates the association between lipid profile and inflammatory markers with the severity and outcome of COVID-19 patients referred to a teaching hospital in Mazandaran Province, Iran, during April-May and July-August 2020.
Methods: This study was conducted on 140 patients with COVID-19 based on their clinical symptoms, imaging results, and laboratory findings. Patients were categorized as severe and non-severe groups based on the Centers for Disease Control and Prevention criteria. Blood samples (5-7 mL) were collected from patients after 12 hours of fasting. Serum triglycerides, cholesterol, highdensity lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels were measured using Pars Azmoon Kits (Hitachi Ltd).
Results: Of 140 COVID-19 patients, 33.57% had severe and 66.43% had non-severe disease. Patients with severe disease had a significantly lower mean LDL serum level than those with non-severe involvement (56.39±3.62 vs 70.10±3.74 mg/dL) (P=0.023). Patients in the intensive care units had significantly lower HDL, LDL, and cholesterol serum levels than those hospitalized in other parts (P=0.006, P=0.002, and P=0.002, respectively). There was a significant negative correlation between HDL serum level and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (P=0.0001 and r=-0.482) and (P=0.01 and r=-0.258), respectively. Additionally, there was a significant correlation between cholesterol level and CRP, triglycerides, and ESR (P=0.016 and P=0.02, respectively).
Conclusion: The present study highlights the potential of lipid profiling as a cost-effective and accessible marker to assess COVID-19 severity and prognosis. |
| format | Article |
| id | doaj-art-fb645a6e364b443eb932878f2425269d |
| institution | OA Journals |
| issn | 2322-1348 2322-133X |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Mazandaran University of Medical Sciences and Health Services |
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| series | Research in Molecular Medicine |
| spelling | doaj-art-fb645a6e364b443eb932878f2425269d2025-08-20T02:14:35ZengMazandaran University of Medical Sciences and Health ServicesResearch in Molecular Medicine2322-13482322-133X2022-11-01104245254Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and OutcomeAmirhossein Khoshgoeian0Adele Bahar1Zahra Kashi2Mina Khasayesi3Shima Yahoo Torghabe4Mahmood Moosazadeh5Zahra Hosseini-khah6 Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Background: COVID-19 is a highly contagious disease that has already affected millions of people worldwide. Proinflammatory cytokines in COVID-19 infection change lipid metabolism and profile. This study investigates the association between lipid profile and inflammatory markers with the severity and outcome of COVID-19 patients referred to a teaching hospital in Mazandaran Province, Iran, during April-May and July-August 2020. Methods: This study was conducted on 140 patients with COVID-19 based on their clinical symptoms, imaging results, and laboratory findings. Patients were categorized as severe and non-severe groups based on the Centers for Disease Control and Prevention criteria. Blood samples (5-7 mL) were collected from patients after 12 hours of fasting. Serum triglycerides, cholesterol, highdensity lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels were measured using Pars Azmoon Kits (Hitachi Ltd). Results: Of 140 COVID-19 patients, 33.57% had severe and 66.43% had non-severe disease. Patients with severe disease had a significantly lower mean LDL serum level than those with non-severe involvement (56.39±3.62 vs 70.10±3.74 mg/dL) (P=0.023). Patients in the intensive care units had significantly lower HDL, LDL, and cholesterol serum levels than those hospitalized in other parts (P=0.006, P=0.002, and P=0.002, respectively). There was a significant negative correlation between HDL serum level and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (P=0.0001 and r=-0.482) and (P=0.01 and r=-0.258), respectively. Additionally, there was a significant correlation between cholesterol level and CRP, triglycerides, and ESR (P=0.016 and P=0.02, respectively). Conclusion: The present study highlights the potential of lipid profiling as a cost-effective and accessible marker to assess COVID-19 severity and prognosis.http://rmm.mazums.ac.ir/article-1-507-en.pdflipid profileinflammatory markersseverityoutcomecovid-19 |
| spellingShingle | Amirhossein Khoshgoeian Adele Bahar Zahra Kashi Mina Khasayesi Shima Yahoo Torghabe Mahmood Moosazadeh Zahra Hosseini-khah Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome Research in Molecular Medicine lipid profile inflammatory markers severity outcome covid-19 |
| title | Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome |
| title_full | Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome |
| title_fullStr | Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome |
| title_full_unstemmed | Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome |
| title_short | Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome |
| title_sort | association of lipid profile and inflammatory markers with covid 19 severity and outcome |
| topic | lipid profile inflammatory markers severity outcome covid-19 |
| url | http://rmm.mazums.ac.ir/article-1-507-en.pdf |
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