Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study
ABSTRACT Background HIV‐associated neurocognitive disorders (HAND), especially asymptomatic neurocognitive impairment (ANI), the initial stage of HAND, persist among a substantial proportion of individuals living with HIV despite the introduction of combination antiretroviral therapy (cART). Resting...
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Wiley
2025-06-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70559 |
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| author | Juming Ma Zhongkai Zhou Shuai Han Chuanke Hou Xingyuan Jiang Fan Xu Haixia Luo Jiaojiao Liu Wei Wang Haiyan Zhao Lingling Zhao Hongjun Li |
| author_facet | Juming Ma Zhongkai Zhou Shuai Han Chuanke Hou Xingyuan Jiang Fan Xu Haixia Luo Jiaojiao Liu Wei Wang Haiyan Zhao Lingling Zhao Hongjun Li |
| author_sort | Juming Ma |
| collection | DOAJ |
| description | ABSTRACT Background HIV‐associated neurocognitive disorders (HAND), especially asymptomatic neurocognitive impairment (ANI), the initial stage of HAND, persist among a substantial proportion of individuals living with HIV despite the introduction of combination antiretroviral therapy (cART). Resting‐state functional magnetic resonance imaging (rs‐fMRI) focusing on ANI among HIV‐related patients is rarely reported. Methods 60 right‐handed Chinese male patients with HIV‐associated ANI underwent baseline and follow‐up neurocognitive examination, and rs‐fMRI scans over an average interval of 1.68 years. Brain function alterations were evaluated through amplitude of low‐frequency fluctuation (ALFF/fALFF), regional homogeneity (ReHo), and functional connectivity (FC) analyses. Results In this study, significant reductions in ALFF were observed in the MOG, cuneus, superior frontal gyrus, and supplementary motor area in the follow‐up group compared to baseline. This was accompanied by increased ALFF in the right insula. ReHo analysis revealed decreased values in the left median cingulate, right calcarine fissure, MOG, and left precentral gyrus, alongside increased ReHo in the supramarginal gyrus, postcentral gyrus, parahippocampal gyrus, and calcarine fissure. FC analysis demonstrated decreased connectivity between the precentral gyrus and calcarine cortex and between the MOG and calcarine cortex. Correlation analysis indicated that these imaging changes were correlated with declines in specific neurocognitive domains, including memory, speed of information processing, and executive function. Conclusion Our research demonstrates a gradual deterioration in brain function in HIV‐positive individuals with ANI despite receiving cART. This decline correlates with worsening neurocognitive abilities, specifically visual processing and executive function. |
| format | Article |
| id | doaj-art-fb6041c845964650b81f4e5887094735 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-fb6041c845964650b81f4e58870947352025-08-20T04:00:50ZengWileyBrain and Behavior2162-32792025-06-01156n/an/a10.1002/brb3.70559Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal StudyJuming Ma0Zhongkai Zhou1Shuai Han2Chuanke Hou3Xingyuan Jiang4Fan Xu5Haixia Luo6Jiaojiao Liu7Wei Wang8Haiyan Zhao9Lingling Zhao10Hongjun Li11Department of Radiology Qilu Hospital of Shandong University Jinan ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaDepartment of Radiology Qilu Hospital of Shandong University Jinan ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaThe Sixth People's Hospital of Zhengzhou Zhengzhou ChinaDepartment of Radiology Beijing Youan Hospital Capital Medical University Beijing ChinaABSTRACT Background HIV‐associated neurocognitive disorders (HAND), especially asymptomatic neurocognitive impairment (ANI), the initial stage of HAND, persist among a substantial proportion of individuals living with HIV despite the introduction of combination antiretroviral therapy (cART). Resting‐state functional magnetic resonance imaging (rs‐fMRI) focusing on ANI among HIV‐related patients is rarely reported. Methods 60 right‐handed Chinese male patients with HIV‐associated ANI underwent baseline and follow‐up neurocognitive examination, and rs‐fMRI scans over an average interval of 1.68 years. Brain function alterations were evaluated through amplitude of low‐frequency fluctuation (ALFF/fALFF), regional homogeneity (ReHo), and functional connectivity (FC) analyses. Results In this study, significant reductions in ALFF were observed in the MOG, cuneus, superior frontal gyrus, and supplementary motor area in the follow‐up group compared to baseline. This was accompanied by increased ALFF in the right insula. ReHo analysis revealed decreased values in the left median cingulate, right calcarine fissure, MOG, and left precentral gyrus, alongside increased ReHo in the supramarginal gyrus, postcentral gyrus, parahippocampal gyrus, and calcarine fissure. FC analysis demonstrated decreased connectivity between the precentral gyrus and calcarine cortex and between the MOG and calcarine cortex. Correlation analysis indicated that these imaging changes were correlated with declines in specific neurocognitive domains, including memory, speed of information processing, and executive function. Conclusion Our research demonstrates a gradual deterioration in brain function in HIV‐positive individuals with ANI despite receiving cART. This decline correlates with worsening neurocognitive abilities, specifically visual processing and executive function.https://doi.org/10.1002/brb3.70559amplitude of low‐frequency fluctuationasymptomatic neurocognitive impairmentfunctional connectivityHIV‐associated neurocognitive disordersregional homogeneity |
| spellingShingle | Juming Ma Zhongkai Zhou Shuai Han Chuanke Hou Xingyuan Jiang Fan Xu Haixia Luo Jiaojiao Liu Wei Wang Haiyan Zhao Lingling Zhao Hongjun Li Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study Brain and Behavior amplitude of low‐frequency fluctuation asymptomatic neurocognitive impairment functional connectivity HIV‐associated neurocognitive disorders regional homogeneity |
| title | Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study |
| title_full | Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study |
| title_fullStr | Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study |
| title_full_unstemmed | Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study |
| title_short | Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study |
| title_sort | examining brain function changes in hiv infected patients with asymptomatic neurocognitive impairment a longitudinal study |
| topic | amplitude of low‐frequency fluctuation asymptomatic neurocognitive impairment functional connectivity HIV‐associated neurocognitive disorders regional homogeneity |
| url | https://doi.org/10.1002/brb3.70559 |
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