Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysis
The systemic review and meta-analysis aimed to identify the predictors for short-term successful weaning from CRRT in severe AKI patients. PubMed, Embase, the Cochrane Library, and grey literature were searched for relevant studies investigating variables for short-term successful weaning from CRRT...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2176170 |
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| _version_ | 1849323701321859072 |
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| author | Yu Li Xiaoqi Deng Jiaxing Feng Bo Xu Yulei Chen Zhanying Li Xiaodan Guo Tianjun Guan |
| author_facet | Yu Li Xiaoqi Deng Jiaxing Feng Bo Xu Yulei Chen Zhanying Li Xiaodan Guo Tianjun Guan |
| author_sort | Yu Li |
| collection | DOAJ |
| description | The systemic review and meta-analysis aimed to identify the predictors for short-term successful weaning from CRRT in severe AKI patients. PubMed, Embase, the Cochrane Library, and grey literature were searched for relevant studies investigating variables for short-term successful weaning from CRRT to August 2022. Our criteria included patients with AKI who required CRRT but excluded patients with kidney failure. The pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect (I2≤50% and P-value of the Q statistic > 0.1) or random-effect models (I2>50% or p-value of the Q statistic ≤ 0.1) as appropriate. Our search yielded 11 studies and described 11 variables. The pooled analysis showed that chronic kidney disease (OR = 0.638, 95% CI: 0.491–0.829), CRRT duration (OR = 0.913, 95% CI: 0.882–0.946), and urine output at the cessation of CRRT (per 100 mL/day increase) (OR = 1.084, 95% CI: 1.061–1.108) were predictive factors for short-term successful weaning from CRRT. Male (OR = 0.827, 95% CI: 0.627-1.092), diabetes mellitus (OR = 0.970, 95% CI: 0.761–1.237), and sepsis (OR = 0.911, 95% CI: 0.717–1.158) were unrelated to the short-term weaning from CRRT. The relationship between hypertension, use of vasopressors or inotropes at the starting of CRRT, use of vasopressors or inotropes at the cessation of CRRT, use of diuretics at the cessation of CRRT, serum creatinine at the cessation of CRRT, and short-term weaning from CRRT remains unclear. Additional prospective studies are needed to evaluate this relationship further. |
| format | Article |
| id | doaj-art-fb56330c98664996bb3e4b28dcfd3b8c |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-fb56330c98664996bb3e4b28dcfd3b8c2025-08-20T03:48:57ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2176170Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysisYu Li0Xiaoqi Deng1Jiaxing Feng2Bo Xu3Yulei Chen4Zhanying Li5Xiaodan Guo6Tianjun Guan7Department of Nephrology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, ChinaDepartment of Nephrology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, ChinaDepartment of Gastroenterology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, ChinaDepartment of Nephrology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaDepartment of Nephrology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, ChinaDepartment of Nephrology, Zhongshan Hospital affiliated to Xiamen University, Xiamen, ChinaThe systemic review and meta-analysis aimed to identify the predictors for short-term successful weaning from CRRT in severe AKI patients. PubMed, Embase, the Cochrane Library, and grey literature were searched for relevant studies investigating variables for short-term successful weaning from CRRT to August 2022. Our criteria included patients with AKI who required CRRT but excluded patients with kidney failure. The pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect (I2≤50% and P-value of the Q statistic > 0.1) or random-effect models (I2>50% or p-value of the Q statistic ≤ 0.1) as appropriate. Our search yielded 11 studies and described 11 variables. The pooled analysis showed that chronic kidney disease (OR = 0.638, 95% CI: 0.491–0.829), CRRT duration (OR = 0.913, 95% CI: 0.882–0.946), and urine output at the cessation of CRRT (per 100 mL/day increase) (OR = 1.084, 95% CI: 1.061–1.108) were predictive factors for short-term successful weaning from CRRT. Male (OR = 0.827, 95% CI: 0.627-1.092), diabetes mellitus (OR = 0.970, 95% CI: 0.761–1.237), and sepsis (OR = 0.911, 95% CI: 0.717–1.158) were unrelated to the short-term weaning from CRRT. The relationship between hypertension, use of vasopressors or inotropes at the starting of CRRT, use of vasopressors or inotropes at the cessation of CRRT, use of diuretics at the cessation of CRRT, serum creatinine at the cessation of CRRT, and short-term weaning from CRRT remains unclear. Additional prospective studies are needed to evaluate this relationship further.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2176170Continuous renal replacement therapyweaningdiscontinuationpredictoracute kidney injurymeta-analysis |
| spellingShingle | Yu Li Xiaoqi Deng Jiaxing Feng Bo Xu Yulei Chen Zhanying Li Xiaodan Guo Tianjun Guan Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysis Renal Failure Continuous renal replacement therapy weaning discontinuation predictor acute kidney injury meta-analysis |
| title | Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysis |
| title_full | Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysis |
| title_fullStr | Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysis |
| title_full_unstemmed | Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysis |
| title_short | Predictors for short-term successful weaning from continuous renal replacement therapy: a systematic review and meta-analysis |
| title_sort | predictors for short term successful weaning from continuous renal replacement therapy a systematic review and meta analysis |
| topic | Continuous renal replacement therapy weaning discontinuation predictor acute kidney injury meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2176170 |
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