Role of bacteria in cancers and their therapeutic potential: Review of current knowledge
Cancers are extremely dynamic diseases that can actively cause refractorines to be gained from applied therapies, which is why they are at the forefront of deaths worldwide. In this literature review, we covered the most recent and important discoveries regarding the influence of human microbiota,...
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| Format: | Article |
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Mashhad University of Medical Sciences
2025-03-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_25366_dd697fc38428bce4b3c670280c27f8ec.pdf |
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| author | Wojciech Wawrety Anna Kedziora |
| author_facet | Wojciech Wawrety Anna Kedziora |
| author_sort | Wojciech Wawrety |
| collection | DOAJ |
| description | Cancers are extremely dynamic diseases that can actively cause refractorines to be gained from applied therapies, which is why they are at the forefront of deaths worldwide. In this literature review, we covered the most recent and important discoveries regarding the influence of human microbiota, including tumor bacteriome, on the development and treatment of cancer. Advances in research on microbial communities have enabled us to discover the role of the human microbiome in the development and course of this disease, helping us understand neoplasms better and design new potential therapies. As we show through our findings, by immunomodulation and the secretion of certain chemical substances, the correct bacteriome of the intestinal tract, respiratory system, or skin can protect humans against cancer development and help during the treatment process. Bacteria also reside inside tumors, forming part of the tumor microenvironment (TME), where they interact with immunological and cancer cells in many complex ways. Some bacteria, such as Pseudomonas aeruginosa or Akkermansia muciniphila, can stimulate anticancer cell-mediated immune responses or even directly lead to cancer cell death. We also present the clinical possibilities of using some live, usually modified bacteria to develop bacteriotherapies. Modifying the gut microbiome to stimulate standard treatment is also important. Research on the microbiome and cancer remains a challenging topic in microbiology, having a great potential for advancements in cancer therapy in the future, and is continuously becoming a more and more popular field of research, as shown by our statistical analysis of PubMed data. |
| format | Article |
| id | doaj-art-fb54b86ff9cb408a8f0379660d1ea73c |
| institution | Kabale University |
| issn | 2008-3866 2008-3874 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj-art-fb54b86ff9cb408a8f0379660d1ea73c2025-08-20T03:56:45ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742025-03-0128327328210.22038/ijbms.2024.77667.1679825366Role of bacteria in cancers and their therapeutic potential: Review of current knowledgeWojciech Wawrety0Anna Kedziora1Department of Microbiology Faculty of Biological Sciences University of Wroclaw Przybyszewskiego 63, 51-148 WroclawDepartment of Microbiology Faculty of Biological Sciences University of Wroclaw Przybyszewskiego 63, 51-148 WroclawCancers are extremely dynamic diseases that can actively cause refractorines to be gained from applied therapies, which is why they are at the forefront of deaths worldwide. In this literature review, we covered the most recent and important discoveries regarding the influence of human microbiota, including tumor bacteriome, on the development and treatment of cancer. Advances in research on microbial communities have enabled us to discover the role of the human microbiome in the development and course of this disease, helping us understand neoplasms better and design new potential therapies. As we show through our findings, by immunomodulation and the secretion of certain chemical substances, the correct bacteriome of the intestinal tract, respiratory system, or skin can protect humans against cancer development and help during the treatment process. Bacteria also reside inside tumors, forming part of the tumor microenvironment (TME), where they interact with immunological and cancer cells in many complex ways. Some bacteria, such as Pseudomonas aeruginosa or Akkermansia muciniphila, can stimulate anticancer cell-mediated immune responses or even directly lead to cancer cell death. We also present the clinical possibilities of using some live, usually modified bacteria to develop bacteriotherapies. Modifying the gut microbiome to stimulate standard treatment is also important. Research on the microbiome and cancer remains a challenging topic in microbiology, having a great potential for advancements in cancer therapy in the future, and is continuously becoming a more and more popular field of research, as shown by our statistical analysis of PubMed data.https://ijbms.mums.ac.ir/article_25366_dd697fc38428bce4b3c670280c27f8ec.pdfbacteriaimmunotherapymicrobiotaneoplasmstumor microenvironment |
| spellingShingle | Wojciech Wawrety Anna Kedziora Role of bacteria in cancers and their therapeutic potential: Review of current knowledge Iranian Journal of Basic Medical Sciences bacteria immunotherapy microbiota neoplasms tumor microenvironment |
| title | Role of bacteria in cancers and their therapeutic potential: Review of current knowledge |
| title_full | Role of bacteria in cancers and their therapeutic potential: Review of current knowledge |
| title_fullStr | Role of bacteria in cancers and their therapeutic potential: Review of current knowledge |
| title_full_unstemmed | Role of bacteria in cancers and their therapeutic potential: Review of current knowledge |
| title_short | Role of bacteria in cancers and their therapeutic potential: Review of current knowledge |
| title_sort | role of bacteria in cancers and their therapeutic potential review of current knowledge |
| topic | bacteria immunotherapy microbiota neoplasms tumor microenvironment |
| url | https://ijbms.mums.ac.ir/article_25366_dd697fc38428bce4b3c670280c27f8ec.pdf |
| work_keys_str_mv | AT wojciechwawrety roleofbacteriaincancersandtheirtherapeuticpotentialreviewofcurrentknowledge AT annakedziora roleofbacteriaincancersandtheirtherapeuticpotentialreviewofcurrentknowledge |