Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery
Hyperbranched polymers (HBPs) have drawn great interest in the biomedical field on account of their special morphology, low viscosity, self-regulation, and facile preparation methods. Moreover, their large intramolecular cavities, high biocompatibility, biodegradability, and targeting properties ren...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Pharmaceutical Analysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S209517792400100X |
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| author | Yuqiong Guo Xinni He Gareth R. Williams Yue Zhou Xinying Liao Ziyi Xiao Cuiyun Yu Yang Liu |
| author_facet | Yuqiong Guo Xinni He Gareth R. Williams Yue Zhou Xinying Liao Ziyi Xiao Cuiyun Yu Yang Liu |
| author_sort | Yuqiong Guo |
| collection | DOAJ |
| description | Hyperbranched polymers (HBPs) have drawn great interest in the biomedical field on account of their special morphology, low viscosity, self-regulation, and facile preparation methods. Moreover, their large intramolecular cavities, high biocompatibility, biodegradability, and targeting properties render them very suitable for anti-tumor drug delivery. Recently, exploiting the specific characteristics of the tumor microenvironment, a range of multifunctional HBPs responsive to the tumor microenvironment have emerged. By further introducing various types of drugs through physical embedding or chemical coupling, the resulting HBPs based delivery systems have played a crucial part in improving drug stability, increasing effective drug concentration, decreasing drug toxicity and side effects, and enhancing anti-tumor effect. Here, based on different types of tumor microenvironment stimulation signals such as pH, redox, temperature, etc., we systematically review the preparation and response mechanism of HBPs, summarize the latest advances in drug delivery applications, and analyze the challenges and future research directions for such nanomaterials in biomedical clinical applications. |
| format | Article |
| id | doaj-art-fb502d7865524675a93d3f54519587e5 |
| institution | Kabale University |
| issn | 2095-1779 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj-art-fb502d7865524675a93d3f54519587e52025-01-30T05:13:58ZengElsevierJournal of Pharmaceutical Analysis2095-17792024-12-011412101003Tumor microenvironment-responsive hyperbranched polymers for controlled drug deliveryYuqiong Guo0Xinni He1Gareth R. Williams2Yue Zhou3Xinying Liao4Ziyi Xiao5Cuiyun Yu6Yang Liu7Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, ChinaUCL School of Pharmacy, University College London, London, WC1N1AX, UKHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, ChinaHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; UCL School of Pharmacy, University College London, London, WC1N1AX, UK; Corresponding author. Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.Hyperbranched polymers (HBPs) have drawn great interest in the biomedical field on account of their special morphology, low viscosity, self-regulation, and facile preparation methods. Moreover, their large intramolecular cavities, high biocompatibility, biodegradability, and targeting properties render them very suitable for anti-tumor drug delivery. Recently, exploiting the specific characteristics of the tumor microenvironment, a range of multifunctional HBPs responsive to the tumor microenvironment have emerged. By further introducing various types of drugs through physical embedding or chemical coupling, the resulting HBPs based delivery systems have played a crucial part in improving drug stability, increasing effective drug concentration, decreasing drug toxicity and side effects, and enhancing anti-tumor effect. Here, based on different types of tumor microenvironment stimulation signals such as pH, redox, temperature, etc., we systematically review the preparation and response mechanism of HBPs, summarize the latest advances in drug delivery applications, and analyze the challenges and future research directions for such nanomaterials in biomedical clinical applications.http://www.sciencedirect.com/science/article/pii/S209517792400100XDrug deliveryHyperbranched polymerStimuli responsiveTumor microenvironment |
| spellingShingle | Yuqiong Guo Xinni He Gareth R. Williams Yue Zhou Xinying Liao Ziyi Xiao Cuiyun Yu Yang Liu Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery Journal of Pharmaceutical Analysis Drug delivery Hyperbranched polymer Stimuli responsive Tumor microenvironment |
| title | Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery |
| title_full | Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery |
| title_fullStr | Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery |
| title_full_unstemmed | Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery |
| title_short | Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery |
| title_sort | tumor microenvironment responsive hyperbranched polymers for controlled drug delivery |
| topic | Drug delivery Hyperbranched polymer Stimuli responsive Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S209517792400100X |
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