Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice
With the rise of probiotics fermentation in food industry, fermented foods have attracted worldwide attention. In this study, protective effects of Rosa roxburghii & edible fungus fermentation broth (REFB) on immune function and gut health in Cyclophosphamide induced immunosuppressed mice we...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-01-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221345302300112X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557753741082624 |
|---|---|
| author | Dechang Xu Jielun Hu Yadong Zhong Yanli Zhang Wenting Liu Shaoping Nie Mingyong Xie |
| author_facet | Dechang Xu Jielun Hu Yadong Zhong Yanli Zhang Wenting Liu Shaoping Nie Mingyong Xie |
| author_sort | Dechang Xu |
| collection | DOAJ |
| description | With the rise of probiotics fermentation in food industry, fermented foods have attracted worldwide attention. In this study, protective effects of Rosa roxburghii & edible fungus fermentation broth (REFB) on immune function and gut health in Cyclophosphamide induced immunosuppressed mice were investigated. Results showed that REFB could improve the immune organ index, and promote the proliferation and differentiation of splenic T lymphocytes. In addition, it attenuated intestinal mucosal damage and improved intestinal cellular immunity. REFB administration also up-regulated the expression of IL-4, INF-γ, TNF-α, T-bet and GATA-3 mRNA in small intestine. Furthermore, administration of REFB modulated gut microbiota composition and increased the relative abundance of beneficial genus, such as Bacteroides. It also increased the production of fecal short-chain fatty acids. These indicate that REFB has the potential to improve immunity, alleviate intestinal injury and regulate gut microbiota in immunosuppressed mice. |
| format | Article |
| id | doaj-art-fb4831cf0768410db2c3a885bbd51bc8 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-fb4831cf0768410db2c3a885bbd51bc82025-02-03T02:51:42ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131154165Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed miceDechang Xu0Jielun Hu1Yadong Zhong2Yanli Zhang3Wenting Liu4Shaoping Nie5Mingyong Xie6State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, ChinaCorresponding author at: State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, China.; State Key Laboratory of Food Science and Technology, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, ChinaWith the rise of probiotics fermentation in food industry, fermented foods have attracted worldwide attention. In this study, protective effects of Rosa roxburghii & edible fungus fermentation broth (REFB) on immune function and gut health in Cyclophosphamide induced immunosuppressed mice were investigated. Results showed that REFB could improve the immune organ index, and promote the proliferation and differentiation of splenic T lymphocytes. In addition, it attenuated intestinal mucosal damage and improved intestinal cellular immunity. REFB administration also up-regulated the expression of IL-4, INF-γ, TNF-α, T-bet and GATA-3 mRNA in small intestine. Furthermore, administration of REFB modulated gut microbiota composition and increased the relative abundance of beneficial genus, such as Bacteroides. It also increased the production of fecal short-chain fatty acids. These indicate that REFB has the potential to improve immunity, alleviate intestinal injury and regulate gut microbiota in immunosuppressed mice.http://www.sciencedirect.com/science/article/pii/S221345302300112XFermented foodsImmunosuppressed miceImmune responseGut microbiotaShort-chain fatty acids |
| spellingShingle | Dechang Xu Jielun Hu Yadong Zhong Yanli Zhang Wenting Liu Shaoping Nie Mingyong Xie Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice Food Science and Human Wellness Fermented foods Immunosuppressed mice Immune response Gut microbiota Short-chain fatty acids |
| title | Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice |
| title_full | Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice |
| title_fullStr | Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice |
| title_full_unstemmed | Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice |
| title_short | Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice |
| title_sort | effects of rosa roxburghii amp edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice |
| topic | Fermented foods Immunosuppressed mice Immune response Gut microbiota Short-chain fatty acids |
| url | http://www.sciencedirect.com/science/article/pii/S221345302300112X |
| work_keys_str_mv | AT dechangxu effectsofrosaroxburghiiampediblefungusfermentationbrothonimmuneresponseandgutmicrobiotainimmunosuppressedmice AT jielunhu effectsofrosaroxburghiiampediblefungusfermentationbrothonimmuneresponseandgutmicrobiotainimmunosuppressedmice AT yadongzhong effectsofrosaroxburghiiampediblefungusfermentationbrothonimmuneresponseandgutmicrobiotainimmunosuppressedmice AT yanlizhang effectsofrosaroxburghiiampediblefungusfermentationbrothonimmuneresponseandgutmicrobiotainimmunosuppressedmice AT wentingliu effectsofrosaroxburghiiampediblefungusfermentationbrothonimmuneresponseandgutmicrobiotainimmunosuppressedmice AT shaopingnie effectsofrosaroxburghiiampediblefungusfermentationbrothonimmuneresponseandgutmicrobiotainimmunosuppressedmice AT mingyongxie effectsofrosaroxburghiiampediblefungusfermentationbrothonimmuneresponseandgutmicrobiotainimmunosuppressedmice |