Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology
Cardiovascular disease poses a significant risk to human health and remains the leading cause of illness and death globally, with its incidence continuing to rise. The intricate pathophysiological mechanisms of CVDs include inflammation, oxidative stress, autophagy, and myocardial fibrosis. In light...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1499060/full |
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| author | Luwen Zhang Luwen Zhang Wei Wang Xincan Liu Kuipo Yan Qiang Li Ming Li Chunying Li Chunying Li Yanxin Li Yanxin Li Lei Chen |
| author_facet | Luwen Zhang Luwen Zhang Wei Wang Xincan Liu Kuipo Yan Qiang Li Ming Li Chunying Li Chunying Li Yanxin Li Yanxin Li Lei Chen |
| author_sort | Luwen Zhang |
| collection | DOAJ |
| description | Cardiovascular disease poses a significant risk to human health and remains the leading cause of illness and death globally, with its incidence continuing to rise. The intricate pathophysiological mechanisms of CVDs include inflammation, oxidative stress, autophagy, and myocardial fibrosis. In light of these underlying mechanisms, traditional Chinese medicine (TCM) and its constituents have demonstrated distinct advantages in managing CVDs. By exerting synergistic effects across multiple components and targets, traditional Chinese medicine can modulate the inflammatory response, mitigate oxidative stress, regulate excessive autophagy, and enhance myocardial fibrosis repair. This article reviews the latest advancements in understanding how TCM compounds regulate signaling pathways involved in the treatment of CVDs. |
| format | Article |
| id | doaj-art-fb3ffdfffaad496ba50d9bcb60d0af9d |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-fb3ffdfffaad496ba50d9bcb60d0af9d2025-08-20T03:10:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.14990601499060Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathologyLuwen Zhang0Luwen Zhang1Wei Wang2Xincan Liu3Kuipo Yan4Qiang Li5Ming Li6Chunying Li7Chunying Li8Yanxin Li9Yanxin Li10Lei Chen11The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Henan Province Traditional Chinese Medicine Epidemic Diseases Engineering Research Center, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Hena University of Chinese Medicine, Henan Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, Henan, ChinaThe First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, Henan, ChinaThe First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, Henan, ChinaThe First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, Henan, ChinaCardiovascular disease poses a significant risk to human health and remains the leading cause of illness and death globally, with its incidence continuing to rise. The intricate pathophysiological mechanisms of CVDs include inflammation, oxidative stress, autophagy, and myocardial fibrosis. In light of these underlying mechanisms, traditional Chinese medicine (TCM) and its constituents have demonstrated distinct advantages in managing CVDs. By exerting synergistic effects across multiple components and targets, traditional Chinese medicine can modulate the inflammatory response, mitigate oxidative stress, regulate excessive autophagy, and enhance myocardial fibrosis repair. This article reviews the latest advancements in understanding how TCM compounds regulate signaling pathways involved in the treatment of CVDs.https://www.frontiersin.org/articles/10.3389/fphar.2025.1499060/fullcardiovascular diseasetraditional Chinese medicinenature compoundssignaling pathwaypharmacokinetic |
| spellingShingle | Luwen Zhang Luwen Zhang Wei Wang Xincan Liu Kuipo Yan Qiang Li Ming Li Chunying Li Chunying Li Yanxin Li Yanxin Li Lei Chen Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology Frontiers in Pharmacology cardiovascular disease traditional Chinese medicine nature compounds signaling pathway pharmacokinetic |
| title | Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology |
| title_full | Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology |
| title_fullStr | Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology |
| title_full_unstemmed | Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology |
| title_short | Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology |
| title_sort | traditional chinese medicine compounds modulate signaling pathways to improve cardiac related pathology |
| topic | cardiovascular disease traditional Chinese medicine nature compounds signaling pathway pharmacokinetic |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1499060/full |
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