Combining ropivacaine transversus abdominis plane block with intravenous lidocaine infusion in adults undergoing colorectal cancer surgery: an open-label, dose-escalation exploratory trial

Combining ropivacaine transversus abdominis plane block with intravenous lidocaine infusion in adults undergoing colorectal cancer surgery: an open-label, dose-escalation exploratory trial

Abstract Background The concurrent use of a ropivacaine transversus abdominis plane (TAP) block with intravenous lidocaine infusion, though effective for pain relief, raises safety concerns regarding local anesthetic systemic toxicity (LAST). This study aimed to assess the dose-risk relationship of...

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Bibliographic Details
Main Authors: Mengmeng Zhou, Feng Yu, Yan Xu, Jingwen Wu, Lajing Luowu, Qianqian Tang, Xiaoting Hao, Kun Shao, Mao Ye, Lulong Bo, Li Zhou, Chunling Jiang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Anesthesiology
Subjects:
Transversus abdominis plane, Ropivacaine, Intravenous lidocaine, Local anesthetic systemic toxicity, Dose-escalation
Online Access:https://doi.org/10.1186/s12871-025-03225-5
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