DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE
The article presents data on the development of a technique for determination of intrinsic viscosity of injectable drug with chondroitin sodium sulfate. A 0.2 M solution of sodium chloride was use as a solvent to eliminate polyelectrolyte swelling. The calculated viscosity of the test solutions was...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/511 |
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| author | K. R. Saveleva L. V. Pesanova V. N. Shestakov S. V. Poliyakov |
| author_facet | K. R. Saveleva L. V. Pesanova V. N. Shestakov S. V. Poliyakov |
| author_sort | K. R. Saveleva |
| collection | DOAJ |
| description | The article presents data on the development of a technique for determination of intrinsic viscosity of injectable drug with chondroitin sodium sulfate. A 0.2 M solution of sodium chloride was use as a solvent to eliminate polyelectrolyte swelling. The calculated viscosity of the test solutions was determinate in the concentration range of chondroitin sulfate 4.5-20 mg /ml. The value of the intrinsic viscosity, determined for each of the tested preparations, was in the range 0.03-0.042 m3/kg. |
| format | Article |
| id | doaj-art-fb3ed8c8b27a4384a19c48285875eb2c |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-fb3ed8c8b27a4384a19c48285875eb2c2025-08-20T03:59:20ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0104154158511DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATEK. R. Saveleva0L. V. Pesanova1V. N. Shestakov2S. V. Poliyakov3State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian FederationState Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian FederationState Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian FederationState Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian FederationThe article presents data on the development of a technique for determination of intrinsic viscosity of injectable drug with chondroitin sodium sulfate. A 0.2 M solution of sodium chloride was use as a solvent to eliminate polyelectrolyte swelling. The calculated viscosity of the test solutions was determinate in the concentration range of chondroitin sulfate 4.5-20 mg /ml. The value of the intrinsic viscosity, determined for each of the tested preparations, was in the range 0.03-0.042 m3/kg.https://www.pharmjournal.ru/jour/article/view/511chondroitin sulfatedrugintramuscular solutionreduced viscosityintrinsic viscosity |
| spellingShingle | K. R. Saveleva L. V. Pesanova V. N. Shestakov S. V. Poliyakov DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE Разработка и регистрация лекарственных средств chondroitin sulfate drug intramuscular solution reduced viscosity intrinsic viscosity |
| title | DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE |
| title_full | DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE |
| title_fullStr | DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE |
| title_full_unstemmed | DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE |
| title_short | DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE |
| title_sort | development of method for determination of intrinsic viscosity of injectable drug with chondroitin sulfate |
| topic | chondroitin sulfate drug intramuscular solution reduced viscosity intrinsic viscosity |
| url | https://www.pharmjournal.ru/jour/article/view/511 |
| work_keys_str_mv | AT krsaveleva developmentofmethodfordeterminationofintrinsicviscosityofinjectabledrugwithchondroitinsulfate AT lvpesanova developmentofmethodfordeterminationofintrinsicviscosityofinjectabledrugwithchondroitinsulfate AT vnshestakov developmentofmethodfordeterminationofintrinsicviscosityofinjectabledrugwithchondroitinsulfate AT svpoliyakov developmentofmethodfordeterminationofintrinsicviscosityofinjectabledrugwithchondroitinsulfate |