PRKCSH enhances colorectal cancer radioresistance via IRE1α/XBP1s-mediated DNA repair

PRKCSH enhances colorectal cancer radioresistance via IRE1α/XBP1s-mediated DNA repair

Abstract Neoadjuvant radiotherapy is the standard treatment for locally advanced rectal cancer, but resistance to this therapy remains a significant clinical challenge. Understanding the molecular mechanisms of radioresistance and developing strategies to enhance radiosensitivity are crucial for imp...

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Main Authors: Hui Shen, Jing Jin, Nanxi Yu, Tingting Liu, Yongzhan Nie, Zhijie Wan, Yuanyuan Chen, Kun Cao, Ying Xu, Yijuan Huang, Chao Feng, Ruixue Huang, Yanyong Yang, Fu Gao
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07582-4
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