Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data
Abstract Tuberculosis is a global public health concern, and understanding Mycobacterium tuberculosis transmission routes and genetic diversity of M. tuberculosis is crucial for outbreak control. This study aimed to explore the genomic epidemiology and genetic diversity of M. tuberculosis in Ecuador...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86079-8 |
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| author | Gabriel Morey-León Paulina M. Mejía-Ponce Juan Carlos Fernández-Cadena Evelyn García-Moreira Derly Andrade-Molina Cuauhtémoc Licona-Cassani Pablo Fresia Luisa Berná |
| author_facet | Gabriel Morey-León Paulina M. Mejía-Ponce Juan Carlos Fernández-Cadena Evelyn García-Moreira Derly Andrade-Molina Cuauhtémoc Licona-Cassani Pablo Fresia Luisa Berná |
| author_sort | Gabriel Morey-León |
| collection | DOAJ |
| description | Abstract Tuberculosis is a global public health concern, and understanding Mycobacterium tuberculosis transmission routes and genetic diversity of M. tuberculosis is crucial for outbreak control. This study aimed to explore the genomic epidemiology and genetic diversity of M. tuberculosis in Ecuador by analyzing 88 local isolates and 415 public genomes from 19 countries within the Euro-American lineage (L4). Our results revealed significant genomic diversity among the isolates, particularly in the genes related to protein processing, carbohydrate metabolism, lipid metabolism, and xenobiotic biodegradation and metabolism. The population structure analysis showed that sub-lineages 4.3.2/3 (35.4%), 4.1.2.1 (22.7%), 4.4.1 (12.7%), and 4.1.1. (10.7%) were the most prevalent. Phylogenetic and transmission network analyses suggest that these isolates circulating within Ecuador share genetic ties with isolates from other continents, implying historical and ongoing intercontinental transmission events. Our findings underscore the importance of integrating genomic data into public health strategies for tuberculosis control and suggest that enhanced genomic surveillance is essential for understanding and mitigating the global spread of M. tuberculosis. This study provides a comprehensive genomic framework for future epidemiological investigations and control measures targeting M. tuberculosis L4 in Ecuador. |
| format | Article |
| id | doaj-art-fb332b31d0f6407f994423aeeb540758 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-fb332b31d0f6407f994423aeeb5407582025-02-02T12:22:03ZengNature PortfolioScientific Reports2045-23222025-01-0115111510.1038/s41598-025-86079-8Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic dataGabriel Morey-León0Paulina M. Mejía-Ponce1Juan Carlos Fernández-Cadena2Evelyn García-Moreira3Derly Andrade-Molina4Cuauhtémoc Licona-Cassani5Pablo Fresia6Luisa Berná7Facultad de Ciencias de la Salud, Universidad Espíritu SantoCentro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de MonterreyLaboratorio de Ciencias Ómicas, Universidad Espíritu SantoInstituto Superior Tecnológico ArgosFacultad de Ciencias de la Salud, Universidad Espíritu SantoCentro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de MonterreyUnidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de MontevideoLaboratorio de Interacciones Hospedero-Patógeno, Unidad de Biología Molecular, Institut Pasteur de MontevideoAbstract Tuberculosis is a global public health concern, and understanding Mycobacterium tuberculosis transmission routes and genetic diversity of M. tuberculosis is crucial for outbreak control. This study aimed to explore the genomic epidemiology and genetic diversity of M. tuberculosis in Ecuador by analyzing 88 local isolates and 415 public genomes from 19 countries within the Euro-American lineage (L4). Our results revealed significant genomic diversity among the isolates, particularly in the genes related to protein processing, carbohydrate metabolism, lipid metabolism, and xenobiotic biodegradation and metabolism. The population structure analysis showed that sub-lineages 4.3.2/3 (35.4%), 4.1.2.1 (22.7%), 4.4.1 (12.7%), and 4.1.1. (10.7%) were the most prevalent. Phylogenetic and transmission network analyses suggest that these isolates circulating within Ecuador share genetic ties with isolates from other continents, implying historical and ongoing intercontinental transmission events. Our findings underscore the importance of integrating genomic data into public health strategies for tuberculosis control and suggest that enhanced genomic surveillance is essential for understanding and mitigating the global spread of M. tuberculosis. This study provides a comprehensive genomic framework for future epidemiological investigations and control measures targeting M. tuberculosis L4 in Ecuador.https://doi.org/10.1038/s41598-025-86079-8EcuadorGenomic clustersGenomic epidemiologySurveillanceTMRCATuberculosis |
| spellingShingle | Gabriel Morey-León Paulina M. Mejía-Ponce Juan Carlos Fernández-Cadena Evelyn García-Moreira Derly Andrade-Molina Cuauhtémoc Licona-Cassani Pablo Fresia Luisa Berná Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data Scientific Reports Ecuador Genomic clusters Genomic epidemiology Surveillance TMRCA Tuberculosis |
| title | Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data |
| title_full | Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data |
| title_fullStr | Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data |
| title_full_unstemmed | Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data |
| title_short | Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data |
| title_sort | global epidemiology of mycobacterium tuberculosis lineage 4 insights from ecuadorian genomic data |
| topic | Ecuador Genomic clusters Genomic epidemiology Surveillance TMRCA Tuberculosis |
| url | https://doi.org/10.1038/s41598-025-86079-8 |
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