Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia
Antipsychotic-induced parkinsonism is an undesirable reaction from the extrapyramidal system that occurs against the background of taking antipsychotics (AP), more often in patients with schizophrenia. Antipsychotic-induced parkinsonism belongs to the group of secondary parkinsonism. Its prevalence...
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| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2021-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/617 |
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| author | E. E. Vaiman N. A. Shnayder N. G. Neznanov R. F. Nasyrova |
| author_facet | E. E. Vaiman N. A. Shnayder N. G. Neznanov R. F. Nasyrova |
| author_sort | E. E. Vaiman |
| collection | DOAJ |
| description | Antipsychotic-induced parkinsonism is an undesirable reaction from the extrapyramidal system that occurs against the background of taking antipsychotics (AP), more often in patients with schizophrenia. Antipsychotic-induced parkinsonism belongs to the group of secondary parkinsonism. Its prevalence in the world is about 36%. It is assumed that this undesirable AP reaction is genetically determined. In recent years, numerous associative genetic studies of predisposition to the development of antipsychotic-induced parkinsonism have been conducted. However, the research results are contradictory.Purpose. Review of the results of studies of genetic predictors of antipsychotic-induced parkinsonism in patients with schizophrenia.Materials and methods. We searched for full-text publications in Russian and English in the RSCI, PubMed, Web of Science, Springer databases using keywords and combined searches for words over the past decade.Results. The review considers candidate genes encoding proteins/enzymes involved in the pharmacodynamics and pharmacokinetics of AP. We analyzed 23 genome-wide studies examining 108 genetic variations, including SNV/polymorphisms of 26 candidate genes involved in the development of AIP in schizophrenic patients. Among such a set of obtained results, only 22 positive associations were revealed: rs1799732 (141CIns/Del), rs1800497 (C/T), rs6275 (C/T) DRD2; rs167771 (G/A) DRD3; VNTR*9R DAT1; rs4680 (G/A) СOMT; rs6311 (C/T) 5HTR2A; rs6318 (C/G), rs3813929 (С/Т), haplotype-997G, -759C, -697C и 68G HTR2C; rs2179652 (C/T), rs2746073 (T/A), rs4606 (C/G), rs1152746 (A/G), rs1819741 (С/Т), rs1933695 (G/A), haplotype rs1933695-G, rs2179652-C, rs4606-C, rs1819741-T и rs1152746-G, haplotype rs1933695-G, rs2179652-T, rs4606-G, rs1819741-C и rs1152746-A RGS2; haplotype TCCTC ADORA2A; rs4795390 (C/G) PPP1R1B; rs6265 (G/A) BDNF; rs12678719 (C/G) ZFPM2; rs938112 (C/A) LSMAP; rs2987902 (A/T) ABL1; HLA-B44; rs16947 (A/G), rs1135824 (A/G), rs3892097 (A/G), rs28371733 (A/G), rs5030867 (A/C), rs5030865 (A/C), rs1065852 (C/T), rs5030863 (C/G), rs5030862 (A/G), rs28371706 (C/T), rs28371725 (A/G), rs1080983 (A/G) CYP2D6. However, at the present time it should be recognized that there is no final or unique decision about the leading role of any particular SNV/polymorphism in the development of AIP.Conclusion. Disclosure of genetic predictors of AP-induced parkinsonism development may provide a key to the development of a strategy for personalized prevention and treatment of the neurological complication of AP-therapy of schizophrenia in real clinical practice. |
| format | Article |
| id | doaj-art-fb2da91eb00c4ca09c7dbb2dffa4a719 |
| institution | DOAJ |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-fb2da91eb00c4ca09c7dbb2dffa4a7192025-08-20T02:49:19ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2021-12-01554153510.31363/2313-7053-2021-57-4-15-35416Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophreniaE. E. Vaiman0N. A. Shnayder1N. G. Neznanov2R. F. Nasyrova3V.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyV.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; V. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityV.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyV.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyAntipsychotic-induced parkinsonism is an undesirable reaction from the extrapyramidal system that occurs against the background of taking antipsychotics (AP), more often in patients with schizophrenia. Antipsychotic-induced parkinsonism belongs to the group of secondary parkinsonism. Its prevalence in the world is about 36%. It is assumed that this undesirable AP reaction is genetically determined. In recent years, numerous associative genetic studies of predisposition to the development of antipsychotic-induced parkinsonism have been conducted. However, the research results are contradictory.Purpose. Review of the results of studies of genetic predictors of antipsychotic-induced parkinsonism in patients with schizophrenia.Materials and methods. We searched for full-text publications in Russian and English in the RSCI, PubMed, Web of Science, Springer databases using keywords and combined searches for words over the past decade.Results. The review considers candidate genes encoding proteins/enzymes involved in the pharmacodynamics and pharmacokinetics of AP. We analyzed 23 genome-wide studies examining 108 genetic variations, including SNV/polymorphisms of 26 candidate genes involved in the development of AIP in schizophrenic patients. Among such a set of obtained results, only 22 positive associations were revealed: rs1799732 (141CIns/Del), rs1800497 (C/T), rs6275 (C/T) DRD2; rs167771 (G/A) DRD3; VNTR*9R DAT1; rs4680 (G/A) СOMT; rs6311 (C/T) 5HTR2A; rs6318 (C/G), rs3813929 (С/Т), haplotype-997G, -759C, -697C и 68G HTR2C; rs2179652 (C/T), rs2746073 (T/A), rs4606 (C/G), rs1152746 (A/G), rs1819741 (С/Т), rs1933695 (G/A), haplotype rs1933695-G, rs2179652-C, rs4606-C, rs1819741-T и rs1152746-G, haplotype rs1933695-G, rs2179652-T, rs4606-G, rs1819741-C и rs1152746-A RGS2; haplotype TCCTC ADORA2A; rs4795390 (C/G) PPP1R1B; rs6265 (G/A) BDNF; rs12678719 (C/G) ZFPM2; rs938112 (C/A) LSMAP; rs2987902 (A/T) ABL1; HLA-B44; rs16947 (A/G), rs1135824 (A/G), rs3892097 (A/G), rs28371733 (A/G), rs5030867 (A/C), rs5030865 (A/C), rs1065852 (C/T), rs5030863 (C/G), rs5030862 (A/G), rs28371706 (C/T), rs28371725 (A/G), rs1080983 (A/G) CYP2D6. However, at the present time it should be recognized that there is no final or unique decision about the leading role of any particular SNV/polymorphism in the development of AIP.Conclusion. Disclosure of genetic predictors of AP-induced parkinsonism development may provide a key to the development of a strategy for personalized prevention and treatment of the neurological complication of AP-therapy of schizophrenia in real clinical practice.https://www.bekhterevreview.com/jour/article/view/617antipsychotics-induced parkinsonismdrug-induced parkinsonismantipsychoticsgenesdrd2drd3dat1сomt5htr2ahtr2crgs2rgs4rgs8rgs9annk1ppp1r1batp1a3adora1adora2aadora3bdnfmnsod (sod2)zfpm2lsmapabl1nqo1gstp1hla-bcyp1a2cyp2d6 |
| spellingShingle | E. E. Vaiman N. A. Shnayder N. G. Neznanov R. F. Nasyrova Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева antipsychotics-induced parkinsonism drug-induced parkinsonism antipsychotics genes drd2 drd3 dat1 сomt 5htr2a htr2c rgs2 rgs4 rgs8 rgs9 annk1 ppp1r1b atp1a3 adora1 adora2a adora3 bdnf mnsod (sod2) zfpm2 lsmap abl1 nqo1 gstp1 hla-b cyp1a2 cyp2d6 |
| title | Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia |
| title_full | Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia |
| title_fullStr | Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia |
| title_full_unstemmed | Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia |
| title_short | Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia |
| title_sort | candidate genes of the development of antipsychotic induced parkinsonism in patients with schizophrenia |
| topic | antipsychotics-induced parkinsonism drug-induced parkinsonism antipsychotics genes drd2 drd3 dat1 сomt 5htr2a htr2c rgs2 rgs4 rgs8 rgs9 annk1 ppp1r1b atp1a3 adora1 adora2a adora3 bdnf mnsod (sod2) zfpm2 lsmap abl1 nqo1 gstp1 hla-b cyp1a2 cyp2d6 |
| url | https://www.bekhterevreview.com/jour/article/view/617 |
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