Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle

Exercise training induces several skeletal muscle adaptations. Beta-guanidinopropionic acid (β-GPA) is a creatine analog that simulates the effect of exercise to induce mitochondrial biogenesis. However, the effects of β-GPA on resistance training adaptation, such as muscle hypertrophy and mitochond...

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Main Authors: Fukao Naoki, Takegaki Junya, Takagi Ryo, Okumura Koki, Fujita Satoshi
Format: Article
Language:English
Published: De Gruyter 2024-12-01
Series:Translational Exercise Biomedicine
Subjects:
Online Access:https://doi.org/10.1515/teb-2024-0035
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author Fukao Naoki
Takegaki Junya
Takagi Ryo
Okumura Koki
Fujita Satoshi
author_facet Fukao Naoki
Takegaki Junya
Takagi Ryo
Okumura Koki
Fujita Satoshi
author_sort Fukao Naoki
collection DOAJ
description Exercise training induces several skeletal muscle adaptations. Beta-guanidinopropionic acid (β-GPA) is a creatine analog that simulates the effect of exercise to induce mitochondrial biogenesis. However, the effects of β-GPA on resistance training adaptation, such as muscle hypertrophy and mitochondrial biogenesis, are unclear. Therefore, using a resistance exercise model in rats, the present study was designed to investigate the effects of β-GPA administration on resistance training adaptations.
format Article
id doaj-art-fb2d2c79fde448c692f38bf4a0da5416
institution DOAJ
issn 2942-6812
language English
publishDate 2024-12-01
publisher De Gruyter
record_format Article
series Translational Exercise Biomedicine
spelling doaj-art-fb2d2c79fde448c692f38bf4a0da54162025-08-20T03:23:16ZengDe GruyterTranslational Exercise Biomedicine2942-68122024-12-0113-429530410.1515/teb-2024-0035Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscleFukao Naoki0Takegaki Junya1Takagi Ryo2Okumura Koki3Fujita Satoshi4Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, JapanResearch Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, JapanRitsumeikan Global Innovation Research Organization, Ritsumeikan University, Kusatsu, JapanGraduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, JapanFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, JapanExercise training induces several skeletal muscle adaptations. Beta-guanidinopropionic acid (β-GPA) is a creatine analog that simulates the effect of exercise to induce mitochondrial biogenesis. However, the effects of β-GPA on resistance training adaptation, such as muscle hypertrophy and mitochondrial biogenesis, are unclear. Therefore, using a resistance exercise model in rats, the present study was designed to investigate the effects of β-GPA administration on resistance training adaptations.https://doi.org/10.1515/teb-2024-0035pgc-1αampkoxphoscalcineurinmuscle proteolysis
spellingShingle Fukao Naoki
Takegaki Junya
Takagi Ryo
Okumura Koki
Fujita Satoshi
Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
Translational Exercise Biomedicine
pgc-1α
ampk
oxphos
calcineurin
muscle proteolysis
title Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
title_full Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
title_fullStr Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
title_full_unstemmed Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
title_short Exogenous Beta-guanidinopropionic acid administration enhances electromyostimulation-induced mitochondrial biogenesis in rat skeletal muscle
title_sort exogenous beta guanidinopropionic acid administration enhances electromyostimulation induced mitochondrial biogenesis in rat skeletal muscle
topic pgc-1α
ampk
oxphos
calcineurin
muscle proteolysis
url https://doi.org/10.1515/teb-2024-0035
work_keys_str_mv AT fukaonaoki exogenousbetaguanidinopropionicacidadministrationenhanceselectromyostimulationinducedmitochondrialbiogenesisinratskeletalmuscle
AT takegakijunya exogenousbetaguanidinopropionicacidadministrationenhanceselectromyostimulationinducedmitochondrialbiogenesisinratskeletalmuscle
AT takagiryo exogenousbetaguanidinopropionicacidadministrationenhanceselectromyostimulationinducedmitochondrialbiogenesisinratskeletalmuscle
AT okumurakoki exogenousbetaguanidinopropionicacidadministrationenhanceselectromyostimulationinducedmitochondrialbiogenesisinratskeletalmuscle
AT fujitasatoshi exogenousbetaguanidinopropionicacidadministrationenhanceselectromyostimulationinducedmitochondrialbiogenesisinratskeletalmuscle