GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH
Transforming growth factor-β1 (TGF-β1) is an important immune regulatorcritical for immune homeostasis. Accumulating evidence suggests that TGF-β1 has acrucial regulatory role in CNS development and potential implications forneurogenesis in a variety of TGF-β1-rel...
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College of Veterinary Medicine, University of Basrah, Iraq
2020-11-01
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| Series: | Basrah Journal of Veterinary Research |
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| Online Access: | https://bjvr.uobasrah.edu.iq/article_174122_b3e49f53156b9a40813e6a6c3fc15e0a.pdf |
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| author | Khulood, Abdulrazaq Kaleel Wijdan, Nazar Ibraheim |
| author_facet | Khulood, Abdulrazaq Kaleel Wijdan, Nazar Ibraheim |
| author_sort | Khulood, Abdulrazaq Kaleel |
| collection | DOAJ |
| description | Transforming growth factor-β1 (TGF-β1) is an important immune regulatorcritical for immune homeostasis. Accumulating evidence suggests that TGF-β1 has acrucial regulatory role in CNS development and potential implications forneurogenesis in a variety of TGF-β1-related CNS diseases: so the aim of the study toinvestigate the association of the TGFβ-1 gene polymorphism with its plasma proteinplasma level (TGFB-1)in ASD patients, It's a case – control study atotal of 94 patientswith ASD, their age ranging from 2 to 13 years and 100 apparently healthy childrenwere used as a control which were matched by age and sex. TGFβ-1 levels wasmeasured by ELISA and TGF-β1(Codon 10 +869 C/T) and TGF-β1(Codon 25:+915*G/C)Gene Polymorphism were detected by specific sets of primers.The meanvalue of TGF-β1 was significantly low in the autistic group (95.91pg / mm) ascompare with the control one (117.08 pg / mm) TGF-β1(Codon 10: +869*T/C) genepolymorphism showed heterogeneous results between autistic group and controlgroup |
| format | Article |
| id | doaj-art-fb2cb64266e843759a302a370dc88338 |
| institution | DOAJ |
| issn | 1813-8497 2410-8456 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | College of Veterinary Medicine, University of Basrah, Iraq |
| record_format | Article |
| series | Basrah Journal of Veterinary Research |
| spelling | doaj-art-fb2cb64266e843759a302a370dc883382025-08-20T03:09:58ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562020-11-0119S1 (Proceeding of 7th International Scientific Conference, College of Veterinary Medicine University of Basrah, Iraq)32033710.23975/bjvetr.2020.174122174122GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAHKhulood, Abdulrazaq Kaleel0Wijdan, Nazar Ibraheim1Department of Microbiology, College of Medicine, University of Basrah, Basrah, IraqDepartment of Microbiology, College of Medicine, University of Basrah, Basrah, IraqTransforming growth factor-β1 (TGF-β1) is an important immune regulatorcritical for immune homeostasis. Accumulating evidence suggests that TGF-β1 has acrucial regulatory role in CNS development and potential implications forneurogenesis in a variety of TGF-β1-related CNS diseases: so the aim of the study toinvestigate the association of the TGFβ-1 gene polymorphism with its plasma proteinplasma level (TGFB-1)in ASD patients, It's a case – control study atotal of 94 patientswith ASD, their age ranging from 2 to 13 years and 100 apparently healthy childrenwere used as a control which were matched by age and sex. TGFβ-1 levels wasmeasured by ELISA and TGF-β1(Codon 10 +869 C/T) and TGF-β1(Codon 25:+915*G/C)Gene Polymorphism were detected by specific sets of primers.The meanvalue of TGF-β1 was significantly low in the autistic group (95.91pg / mm) ascompare with the control one (117.08 pg / mm) TGF-β1(Codon 10: +869*T/C) genepolymorphism showed heterogeneous results between autistic group and controlgrouphttps://bjvr.uobasrah.edu.iq/article_174122_b3e49f53156b9a40813e6a6c3fc15e0a.pdfasdtgfb1gene polymorphism |
| spellingShingle | Khulood, Abdulrazaq Kaleel Wijdan, Nazar Ibraheim GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH Basrah Journal of Veterinary Research asd tgfb1 gene polymorphism |
| title | GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH |
| title_full | GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH |
| title_fullStr | GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH |
| title_full_unstemmed | GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH |
| title_short | GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH |
| title_sort | gene polymorphisim of transforming growth factor beta 1 tgf β1 in autism spectrum disorder asd in basrah |
| topic | asd tgfb1 gene polymorphism |
| url | https://bjvr.uobasrah.edu.iq/article_174122_b3e49f53156b9a40813e6a6c3fc15e0a.pdf |
| work_keys_str_mv | AT khuloodabdulrazaqkaleel genepolymorphisimoftransforminggrowthfactorbeta1tgfb1inautismspectrumdisorderasdinbasrah AT wijdannazaribraheim genepolymorphisimoftransforminggrowthfactorbeta1tgfb1inautismspectrumdisorderasdinbasrah |