RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies
RETRACTED ARTICLEThe aim of the study was to evaluate the relationship between chemotherapy and autoimmune reactions in patients with metastatic colorectal cancer. Cancer and autoimmunity are known to be interrelated, but until now it has been unclear to what extent chemotherapy specifically contrib...
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| Format: | Article |
| Language: | Russian |
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Private institution educational organization of higher education "Medical University "ReaViz"
2023-07-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
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| Online Access: | https://vestnik.reaviz.ru/jour/article/view/811 |
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| author | E. V. Shanina F. Breker N. A. Lysov V. Yu. Shanin Yu. V. Ponomareva A. A. Supil'nikov |
| author_facet | E. V. Shanina F. Breker N. A. Lysov V. Yu. Shanin Yu. V. Ponomareva A. A. Supil'nikov |
| author_sort | E. V. Shanina |
| collection | DOAJ |
| description | RETRACTED ARTICLEThe aim of the study was to evaluate the relationship between chemotherapy and autoimmune reactions in patients with metastatic colorectal cancer. Cancer and autoimmunity are known to be interrelated, but until now it has been unclear to what extent chemotherapy specifically contributes to autoimmune reactions. We studied immunoglobulin M (IgM) levels in response to the administration of various human tissues before and during adjuvant chemotherapy. Patients received seven cycles of chemotherapy with the FOLFIRI plus cetuximab regimen. IgM levels against the tested tissues increased already after the first cycle of chemotherapy and continued to increase during the second and third cycles. Autoimmune responses then began to decrease from the fourth to seventh cycles, but remained elevated from baseline for most of the study tissues. Our results suggest that chemotherapy can induce a wide range of autoimmune reactions. Monitoring self-reactive IgM responses during treatment may help prevent or alleviate side effects associated with autoimmunity. |
| format | Article |
| id | doaj-art-fb2a1524b178496caacd00deabf87a39 |
| institution | Kabale University |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-fb2a1524b178496caacd00deabf87a392025-08-20T03:59:12ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792023-07-0113310410910.20340/vmi-rvz.2023.3.CLIN.12492RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignanciesE. V. Shanina0F. Breker1N. A. Lysov2V. Yu. Shanin3Yu. V. Ponomareva4A. A. Supil'nikov5OncoVax Theranostics Co.LtdOncoVax Theranostics Co.LtdMedical University “Reaviz”Medical University “Reaviz”Medical University “Reaviz”Medical University “Reaviz”RETRACTED ARTICLEThe aim of the study was to evaluate the relationship between chemotherapy and autoimmune reactions in patients with metastatic colorectal cancer. Cancer and autoimmunity are known to be interrelated, but until now it has been unclear to what extent chemotherapy specifically contributes to autoimmune reactions. We studied immunoglobulin M (IgM) levels in response to the administration of various human tissues before and during adjuvant chemotherapy. Patients received seven cycles of chemotherapy with the FOLFIRI plus cetuximab regimen. IgM levels against the tested tissues increased already after the first cycle of chemotherapy and continued to increase during the second and third cycles. Autoimmune responses then began to decrease from the fourth to seventh cycles, but remained elevated from baseline for most of the study tissues. Our results suggest that chemotherapy can induce a wide range of autoimmune reactions. Monitoring self-reactive IgM responses during treatment may help prevent or alleviate side effects associated with autoimmunity.https://vestnik.reaviz.ru/jour/article/view/811colorectal canceradenocarcinomachemotherapytoxicityautoimmunityigmrapid diagnosisagglutination assay |
| spellingShingle | E. V. Shanina F. Breker N. A. Lysov V. Yu. Shanin Yu. V. Ponomareva A. A. Supil'nikov RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье colorectal cancer adenocarcinoma chemotherapy toxicity autoimmunity igm rapid diagnosis agglutination assay |
| title | RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies |
| title_full | RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies |
| title_fullStr | RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies |
| title_full_unstemmed | RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies |
| title_short | RETRACTED: Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies |
| title_sort | retracted chemotherapy induced broadly reactive autoantibodies in the treatment of malignancies |
| topic | colorectal cancer adenocarcinoma chemotherapy toxicity autoimmunity igm rapid diagnosis agglutination assay |
| url | https://vestnik.reaviz.ru/jour/article/view/811 |
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