Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain.
<h4>Background</h4>Successful weight maintenance following weight loss is challenging for many people. Identifying predictors of longer-term success will help target clinical resources more effectively. To date, focus has been predominantly on the identification of predictors of weight l...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042858&type=printable |
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| author | Monica H T Wong Claus Holst Arne Astrup Teodora Handjieva-Darlenska Susan A Jebb Anthony Kafatos Marie Kunesova Thomas M Larsen J Alfredo Martinez Andreas F H Pfeiffer Marleen A van Baak Wim H M Saris Paul D McNicholas David M Mutch DiOGenes |
| author_facet | Monica H T Wong Claus Holst Arne Astrup Teodora Handjieva-Darlenska Susan A Jebb Anthony Kafatos Marie Kunesova Thomas M Larsen J Alfredo Martinez Andreas F H Pfeiffer Marleen A van Baak Wim H M Saris Paul D McNicholas David M Mutch DiOGenes |
| author_sort | Monica H T Wong |
| collection | DOAJ |
| description | <h4>Background</h4>Successful weight maintenance following weight loss is challenging for many people. Identifying predictors of longer-term success will help target clinical resources more effectively. To date, focus has been predominantly on the identification of predictors of weight loss. The goal of the current study was to determine if changes in anthropometric and clinical parameters during acute weight loss are associated with subsequent weight regain.<h4>Methodology</h4>The study consisted of an 8-week low calorie diet (LCD) followed by a 6-month weight maintenance phase. Anthropometric and clinical parameters were analyzed before and after the LCD in the 285 participants (112 men, 173 women) who regained weight during the weight maintenance phase. Mixed model ANOVA, Spearman correlation, and linear regression were used to study the relationships between clinical measurements and weight regain.<h4>Principal findings</h4>Gender differences were observed for body weight and several clinical parameters at both baseline and during the LCD-induced weight loss phase. LCD-induced changes in BMI (Spearman's ρ = 0.22, p = 0.0002) were inversely associated with weight regain in both men and women. LCD-induced changes in fasting insulin (ρ = 0.18, p = 0.0043) and HOMA-IR (ρ = 0.19, p = 0.0023) were also associated independently with weight regain in both genders. The aforementioned associations remained statistically significant in regression models taking account of variables known to independently influence body weight.<h4>Conclusions/significance</h4>LCD-induced changes in BMI, fasting insulin, and HOMA-IR are inversely associated with weight regain in the 6-month period following weight loss. |
| format | Article |
| id | doaj-art-fb28ccd4d98e4720972e31f47fb4f30a |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fb28ccd4d98e4720972e31f47fb4f30a2025-08-20T03:46:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4285810.1371/journal.pone.0042858Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain.Monica H T WongClaus HolstArne AstrupTeodora Handjieva-DarlenskaSusan A JebbAnthony KafatosMarie KunesovaThomas M LarsenJ Alfredo MartinezAndreas F H PfeifferMarleen A van BaakWim H M SarisPaul D McNicholasDavid M MutchDiOGenes<h4>Background</h4>Successful weight maintenance following weight loss is challenging for many people. Identifying predictors of longer-term success will help target clinical resources more effectively. To date, focus has been predominantly on the identification of predictors of weight loss. The goal of the current study was to determine if changes in anthropometric and clinical parameters during acute weight loss are associated with subsequent weight regain.<h4>Methodology</h4>The study consisted of an 8-week low calorie diet (LCD) followed by a 6-month weight maintenance phase. Anthropometric and clinical parameters were analyzed before and after the LCD in the 285 participants (112 men, 173 women) who regained weight during the weight maintenance phase. Mixed model ANOVA, Spearman correlation, and linear regression were used to study the relationships between clinical measurements and weight regain.<h4>Principal findings</h4>Gender differences were observed for body weight and several clinical parameters at both baseline and during the LCD-induced weight loss phase. LCD-induced changes in BMI (Spearman's ρ = 0.22, p = 0.0002) were inversely associated with weight regain in both men and women. LCD-induced changes in fasting insulin (ρ = 0.18, p = 0.0043) and HOMA-IR (ρ = 0.19, p = 0.0023) were also associated independently with weight regain in both genders. The aforementioned associations remained statistically significant in regression models taking account of variables known to independently influence body weight.<h4>Conclusions/significance</h4>LCD-induced changes in BMI, fasting insulin, and HOMA-IR are inversely associated with weight regain in the 6-month period following weight loss.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042858&type=printable |
| spellingShingle | Monica H T Wong Claus Holst Arne Astrup Teodora Handjieva-Darlenska Susan A Jebb Anthony Kafatos Marie Kunesova Thomas M Larsen J Alfredo Martinez Andreas F H Pfeiffer Marleen A van Baak Wim H M Saris Paul D McNicholas David M Mutch DiOGenes Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain. PLoS ONE |
| title | Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain. |
| title_full | Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain. |
| title_fullStr | Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain. |
| title_full_unstemmed | Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain. |
| title_short | Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain. |
| title_sort | caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042858&type=printable |
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