Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging
Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for cancer photothermal treatment (PTT). To mitigate this problem, PTT mediated by photothermal agents (PTAs) has been established as a potential therapeutic techn...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023006853 |
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| author | Farouk Nouizi Maha Algarawi Hakan Erkol Gultekin Gulsen |
| author_facet | Farouk Nouizi Maha Algarawi Hakan Erkol Gultekin Gulsen |
| author_sort | Farouk Nouizi |
| collection | DOAJ |
| description | Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for cancer photothermal treatment (PTT). To mitigate this problem, PTT mediated by photothermal agents (PTAs) has been established as a potential therapeutic technique to boost selectivity and reduce damage to surrounding healthy tissues. Various gold nanoparticles (AuNP) have been effectively utilized as PTAs, mainly using strategies to target cancerous tissue and increase selective thermal damage. Meanwhile, imaging can be used in tandem to monitor the AuNP distribution and guide the PTT. Mainly, the parameters impacting the induced temperature can be determined using simulation tools before treatment for effective PTT. However, accurate simulations can only be performed if the amount of AuNPs accumulated in the tumor is known. This study introduces Photo-Magnetic Imaging (PMI), which can appropriately recover the AuNP concentration to guide the PTT. Using multi-wavelength measurements, PMI can provide AuNP concentration based on their distinct absorption spectra. Tissue-simulating phantom studies are conducted to demonstrate the potential of PMI in recovering AuNP concentration for PTT planning. The recovered AuNP concentration is used to model the temperature increase accurately in a small inclusion representing tumor using a multiphysics solver that takes into account the light propagation and heat diffusion in turbid media. |
| format | Article |
| id | doaj-art-fb25caed5b384dd3bb70db776691c84b |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-fb25caed5b384dd3bb70db776691c84b2025-08-20T01:54:51ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510395610.1016/j.pdpdt.2023.103956Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imagingFarouk Nouizi0Maha Algarawi1Hakan Erkol2Gultekin Gulsen3Department of Radiological Sciences, University of California Irvine, USADepartment of Physics, Imam Mohammad Ibn Saud Islamic University (IMSIU), Saudi ArabiaDepartment of Physics, Bogazici University, TurkeyDepartment of Radiological Sciences, University of California Irvine, USA; Corresponding author.Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for cancer photothermal treatment (PTT). To mitigate this problem, PTT mediated by photothermal agents (PTAs) has been established as a potential therapeutic technique to boost selectivity and reduce damage to surrounding healthy tissues. Various gold nanoparticles (AuNP) have been effectively utilized as PTAs, mainly using strategies to target cancerous tissue and increase selective thermal damage. Meanwhile, imaging can be used in tandem to monitor the AuNP distribution and guide the PTT. Mainly, the parameters impacting the induced temperature can be determined using simulation tools before treatment for effective PTT. However, accurate simulations can only be performed if the amount of AuNPs accumulated in the tumor is known. This study introduces Photo-Magnetic Imaging (PMI), which can appropriately recover the AuNP concentration to guide the PTT. Using multi-wavelength measurements, PMI can provide AuNP concentration based on their distinct absorption spectra. Tissue-simulating phantom studies are conducted to demonstrate the potential of PMI in recovering AuNP concentration for PTT planning. The recovered AuNP concentration is used to model the temperature increase accurately in a small inclusion representing tumor using a multiphysics solver that takes into account the light propagation and heat diffusion in turbid media.http://www.sciencedirect.com/science/article/pii/S1572100023006853Photo-magnetic imagingPhotothermal therapyPhotothermal agentsGold nanoparticlesMulti-wavelength imagingMagnetic resonance thermometry |
| spellingShingle | Farouk Nouizi Maha Algarawi Hakan Erkol Gultekin Gulsen Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging Photodiagnosis and Photodynamic Therapy Photo-magnetic imaging Photothermal therapy Photothermal agents Gold nanoparticles Multi-wavelength imaging Magnetic resonance thermometry |
| title | Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging |
| title_full | Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging |
| title_fullStr | Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging |
| title_full_unstemmed | Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging |
| title_short | Gold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging |
| title_sort | gold nanoparticle mediated photothermal therapy guidance with multi wavelength photomagnetic imaging |
| topic | Photo-magnetic imaging Photothermal therapy Photothermal agents Gold nanoparticles Multi-wavelength imaging Magnetic resonance thermometry |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023006853 |
| work_keys_str_mv | AT farouknouizi goldnanoparticlemediatedphotothermaltherapyguidancewithmultiwavelengthphotomagneticimaging AT mahaalgarawi goldnanoparticlemediatedphotothermaltherapyguidancewithmultiwavelengthphotomagneticimaging AT hakanerkol goldnanoparticlemediatedphotothermaltherapyguidancewithmultiwavelengthphotomagneticimaging AT gultekingulsen goldnanoparticlemediatedphotothermaltherapyguidancewithmultiwavelengthphotomagneticimaging |