Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia
ContextCardiometabolic complications are increasingly recognized in congenital adrenal hyperplasia (CAH) due to 21β-hydroxylase deficiency, but adult data remain limited.ObjectiveTo evaluate cardiovascular and metabolic alterations in adult patients with classic CAH under glucocorticoid treatment, c...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1660114/full |
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| author | Lorenzo Campioni Lorenzo Campioni Maria Chiara Di Carlo Maria Chiara Di Carlo Chiara Sola Chiara Sola Beatrice Bergoglio Beatrice Bergoglio Martina Bollati Martina Bollati Giulia Montesano Federico Ponzetto Federico Ponzetto Chiara Lopez Chiara Lopez Giovanna Motta Giovanna Motta Mirko Parasiliti-Caprino Mirko Parasiliti-Caprino Roberta Giordano Roberta Giordano |
| author_facet | Lorenzo Campioni Lorenzo Campioni Maria Chiara Di Carlo Maria Chiara Di Carlo Chiara Sola Chiara Sola Beatrice Bergoglio Beatrice Bergoglio Martina Bollati Martina Bollati Giulia Montesano Federico Ponzetto Federico Ponzetto Chiara Lopez Chiara Lopez Giovanna Motta Giovanna Motta Mirko Parasiliti-Caprino Mirko Parasiliti-Caprino Roberta Giordano Roberta Giordano |
| author_sort | Lorenzo Campioni |
| collection | DOAJ |
| description | ContextCardiometabolic complications are increasingly recognized in congenital adrenal hyperplasia (CAH) due to 21β-hydroxylase deficiency, but adult data remain limited.ObjectiveTo evaluate cardiovascular and metabolic alterations in adult patients with classic CAH under glucocorticoid treatment, compared to matched controls.MethodsA cross-sectional study was conducted on adults with classic CAH and sex- and BMI-matched controls. Cardiovascular and metabolic variables and parameters were collected in all patients.ResultsThe study enrolled 32 CAH patients and 73 controls. In univariate analyses, CAH patients showed significantly shorter QTc intervals (p=0.004), longer QRS duration and shorter RR intervals, in comparison with controls. Even in presence of a more favorable hypertensive (lower diastolic blood pressure and higher heart rate variability) and metabolic profile (lower fasting glucose, LDL cholesterol, triglycerides, and higher HDL), CAH patients had higher Ambulatory Arterial Stiffness Index (AASI) (p=0.006). Multivariate regression confirmed the association between CAH and both increased AASI (EC 1.131, p<0.001) and shortened QTc (EC 0.977, p=0.039), adjusting for all potential confounders. Within the CAH group, 17-hydroxyprogesterone was positively associated with AASI (EC 1.001, p=0.049), while ACTH (EC 0.999, p=0.021) was inversely associated with QTc, after correction for all clinical confounders. Propensity score-matched analysis with 1:2 matching ratio, based on the same regression models, confirmed that CAH diagnosis was associated with AASI (p<0.001) and QTc (p=0.004).ConclusionsAdults with classic CAH show increased arterial stiffness and altered cardiac repolarization, likely linked to chronic hormonal imbalance. These findings underscore the need for cardiovascular monitoring in long-term CAH management. |
| format | Article |
| id | doaj-art-fb1e1a3567f9462d8bbb4c740f873f40 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-fb1e1a3567f9462d8bbb4c740f873f402025-08-22T04:10:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.16601141660114Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasiaLorenzo Campioni0Lorenzo Campioni1Maria Chiara Di Carlo2Maria Chiara Di Carlo3Chiara Sola4Chiara Sola5Beatrice Bergoglio6Beatrice Bergoglio7Martina Bollati8Martina Bollati9Giulia Montesano10Federico Ponzetto11Federico Ponzetto12Chiara Lopez13Chiara Lopez14Giovanna Motta15Giovanna Motta16Mirko Parasiliti-Caprino17Mirko Parasiliti-Caprino18Roberta Giordano19Roberta Giordano20Endocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyEndocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyEndocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyEndocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyEndocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyClinical Biochemistry Laboratory, City of Health and Science University Hospital, Turin, ItalyEndocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyEndocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyEndocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyDepartment of Medical Sciences, University of Turin, Turin, ItalyDepartment of Biological and Clinical Sciences, University of Turin, Turin, ItalyContextCardiometabolic complications are increasingly recognized in congenital adrenal hyperplasia (CAH) due to 21β-hydroxylase deficiency, but adult data remain limited.ObjectiveTo evaluate cardiovascular and metabolic alterations in adult patients with classic CAH under glucocorticoid treatment, compared to matched controls.MethodsA cross-sectional study was conducted on adults with classic CAH and sex- and BMI-matched controls. Cardiovascular and metabolic variables and parameters were collected in all patients.ResultsThe study enrolled 32 CAH patients and 73 controls. In univariate analyses, CAH patients showed significantly shorter QTc intervals (p=0.004), longer QRS duration and shorter RR intervals, in comparison with controls. Even in presence of a more favorable hypertensive (lower diastolic blood pressure and higher heart rate variability) and metabolic profile (lower fasting glucose, LDL cholesterol, triglycerides, and higher HDL), CAH patients had higher Ambulatory Arterial Stiffness Index (AASI) (p=0.006). Multivariate regression confirmed the association between CAH and both increased AASI (EC 1.131, p<0.001) and shortened QTc (EC 0.977, p=0.039), adjusting for all potential confounders. Within the CAH group, 17-hydroxyprogesterone was positively associated with AASI (EC 1.001, p=0.049), while ACTH (EC 0.999, p=0.021) was inversely associated with QTc, after correction for all clinical confounders. Propensity score-matched analysis with 1:2 matching ratio, based on the same regression models, confirmed that CAH diagnosis was associated with AASI (p<0.001) and QTc (p=0.004).ConclusionsAdults with classic CAH show increased arterial stiffness and altered cardiac repolarization, likely linked to chronic hormonal imbalance. These findings underscore the need for cardiovascular monitoring in long-term CAH management.https://www.frontiersin.org/articles/10.3389/fendo.2025.1660114/fullcardiovascular riskcongenital adrenal hyperplasia21-hydroxylase deficiencyarterial stiffnessandrogensACTH |
| spellingShingle | Lorenzo Campioni Lorenzo Campioni Maria Chiara Di Carlo Maria Chiara Di Carlo Chiara Sola Chiara Sola Beatrice Bergoglio Beatrice Bergoglio Martina Bollati Martina Bollati Giulia Montesano Federico Ponzetto Federico Ponzetto Chiara Lopez Chiara Lopez Giovanna Motta Giovanna Motta Mirko Parasiliti-Caprino Mirko Parasiliti-Caprino Roberta Giordano Roberta Giordano Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia Frontiers in Endocrinology cardiovascular risk congenital adrenal hyperplasia 21-hydroxylase deficiency arterial stiffness androgens ACTH |
| title | Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia |
| title_full | Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia |
| title_fullStr | Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia |
| title_full_unstemmed | Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia |
| title_short | Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia |
| title_sort | arterial stiffness and shortened qtc interval are associated with androgen and acth levels in classic congenital adrenal hyperplasia |
| topic | cardiovascular risk congenital adrenal hyperplasia 21-hydroxylase deficiency arterial stiffness androgens ACTH |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1660114/full |
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