MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction‐Regulating Proteins in a Rat Model of HFpEF

MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction‐Regulating Proteins in a Rat Model of HFpEF

ABSTRACT Background Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance, accompanied by alterations in the peripheral skeletal muscle (SKM). We have recently shown that titin, a giant sarcomere protein, is hyperphosphorylated in HFpEF. MuRF1 is a muscle‐spe...

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Bibliographic Details
Main Authors: Beatrice Vahle, Antje Schauer, Antje Augstein, Maria‐Elisa Prieto Jarabo, Janet Friedrich, Peggy Barthel, Anita Männel, Norman Mangner, Siegfried Labeit, T. Scott Bowen, Axel Linke, Volker Adams
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
atrophy
contractile proteins
HFpEF
MuRF1
MyoMed205
sarcopenia
Online Access:https://doi.org/10.1002/jcsm.13843
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