A liquid chromatography-high-resolution mass spectrometry method for separation and identification of hemoglobin variant subunits with mass shifts less than 1 Da
Background: Identification of hemoglobin (Hb) variants is valuable in clinical testing. A common issue with conventional methods for identifying Hb variants is their subpar ability to provide structural breakdowns of the variants. Reports have surfaced of high-resolution mass spectrometry (HR-MS) me...
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Main Authors: | Ainslie Chen, Ryan M. Aquino, Hector A. Vidal, Carolyn V. Wong, Ruben Y. Luo |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-01-01
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Series: | Journal of Mass Spectrometry and Advances in the Clinical Lab |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2667145X25000021 |
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