Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat model
Background Periodontitis is a widespread chronic inflammatory disease impacting 20–50% of the global population.Methods This study evaluated the effects of Weissella cibaria CMU (CMU) on preventing the progression of periodontitis in a rat model. Periodontitis was induced by injecting lipopolysaccha...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2025.2469895 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850139985739513856 |
|---|---|
| author | Kyung-Hyo Do Soyoung Boo Rayoung You Sanggu Kim Soochong Kim Kwang-Won Seo Mi-Sun Kang Wan-Kyu Lee |
| author_facet | Kyung-Hyo Do Soyoung Boo Rayoung You Sanggu Kim Soochong Kim Kwang-Won Seo Mi-Sun Kang Wan-Kyu Lee |
| author_sort | Kyung-Hyo Do |
| collection | DOAJ |
| description | Background Periodontitis is a widespread chronic inflammatory disease impacting 20–50% of the global population.Methods This study evaluated the effects of Weissella cibaria CMU (CMU) on preventing the progression of periodontitis in a rat model. Periodontitis was induced by injecting lipopolysaccharide into the palatal gingiva around the first and second maxillary molars. CMU was then administered at three concentrations (low: 2 × 107 CFU/rat/day; mid: 2 × 108 CFU/rat/day; high: 2 × 109 CFU/rat/day) for 14 days to assess its ability to prevent further periodontal damage.Results The administration of CMU significantly improved gingivitis and plaque indices in a dose-dependent manner. Macroscopic analysis and micro-computed tomography showed a dose-dependent reduction in alveolar bone loss in the CMU groups. Although histopathological analysis indicated a decrease in bone loss, statistical significance was not achieved in the high-dose group. Pro-inflammatory mediators such as TNF-α, IL-6, MMP-1, and MMP-9 were suppressed in a dose-dependent manner in the CMU groups. Additionally, mid- and high-dose CMU increased the relative abundance of Weissella in the oral microbiome.Conclusions CMU can influence the oral microbiome, reduce inflammatory mediators, and alleviate histological changes in periodontal tissue, highlighting its potential as a probiotic strain for preventing periodontitis. |
| format | Article |
| id | doaj-art-fb13407ca51b42468fbb07e2b0e333b9 |
| institution | OA Journals |
| issn | 2000-2297 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-fb13407ca51b42468fbb07e2b0e333b92025-08-20T02:30:00ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972025-12-0117110.1080/20002297.2025.2469895Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat modelKyung-Hyo Do0Soyoung Boo1Rayoung You2Sanggu Kim3Soochong Kim4Kwang-Won Seo5Mi-Sun Kang6Wan-Kyu Lee7College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaCollege of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaCollege of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaLaboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaCollege of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaR&D Center, OraTicx Inc., Seoul, Republic of KoreaCollege of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of KoreaBackground Periodontitis is a widespread chronic inflammatory disease impacting 20–50% of the global population.Methods This study evaluated the effects of Weissella cibaria CMU (CMU) on preventing the progression of periodontitis in a rat model. Periodontitis was induced by injecting lipopolysaccharide into the palatal gingiva around the first and second maxillary molars. CMU was then administered at three concentrations (low: 2 × 107 CFU/rat/day; mid: 2 × 108 CFU/rat/day; high: 2 × 109 CFU/rat/day) for 14 days to assess its ability to prevent further periodontal damage.Results The administration of CMU significantly improved gingivitis and plaque indices in a dose-dependent manner. Macroscopic analysis and micro-computed tomography showed a dose-dependent reduction in alveolar bone loss in the CMU groups. Although histopathological analysis indicated a decrease in bone loss, statistical significance was not achieved in the high-dose group. Pro-inflammatory mediators such as TNF-α, IL-6, MMP-1, and MMP-9 were suppressed in a dose-dependent manner in the CMU groups. Additionally, mid- and high-dose CMU increased the relative abundance of Weissella in the oral microbiome.Conclusions CMU can influence the oral microbiome, reduce inflammatory mediators, and alleviate histological changes in periodontal tissue, highlighting its potential as a probiotic strain for preventing periodontitis.https://www.tandfonline.com/doi/10.1080/20002297.2025.2469895Periodontal disease(s)/periodontitisoral hygieneprobioticsmicrobiomeinflammationmicrobiology |
| spellingShingle | Kyung-Hyo Do Soyoung Boo Rayoung You Sanggu Kim Soochong Kim Kwang-Won Seo Mi-Sun Kang Wan-Kyu Lee Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat model Journal of Oral Microbiology Periodontal disease(s)/periodontitis oral hygiene probiotics microbiome inflammation microbiology |
| title | Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat model |
| title_full | Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat model |
| title_fullStr | Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat model |
| title_full_unstemmed | Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat model |
| title_short | Preventive effects of Weissella cibaria CMU on the progression of periodontitis in a rat model |
| title_sort | preventive effects of weissella cibaria cmu on the progression of periodontitis in a rat model |
| topic | Periodontal disease(s)/periodontitis oral hygiene probiotics microbiome inflammation microbiology |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2025.2469895 |
| work_keys_str_mv | AT kyunghyodo preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel AT soyoungboo preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel AT rayoungyou preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel AT sanggukim preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel AT soochongkim preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel AT kwangwonseo preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel AT misunkang preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel AT wankyulee preventiveeffectsofweissellacibariacmuontheprogressionofperiodontitisinaratmodel |