Associations of hemoglobin A1c with cognition reduced for long diabetes duration
Abstract Introduction Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this stu...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.11.009 |
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| author | Jeremy M. Silverman James Schmeidler Pearl G. Lee Neil B. Alexander Michal Schnaider Beeri Elizabeth Guerrero‐Berroa Rebecca K. West Mary Sano Martina Nabozny Carolina Rodriguez Alvarez |
| author_facet | Jeremy M. Silverman James Schmeidler Pearl G. Lee Neil B. Alexander Michal Schnaider Beeri Elizabeth Guerrero‐Berroa Rebecca K. West Mary Sano Martina Nabozny Carolina Rodriguez Alvarez |
| author_sort | Jeremy M. Silverman |
| collection | DOAJ |
| description | Abstract Introduction Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration. Methods The interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 “young‐old” veterans (mean age = 70) with type 2 diabetes. Results The predicted interactions were significant for overall cognition and attention, but not executive functions/language and memory. Discussion Findings extend the Protected Survivor Model to a “young‐old” sample, from the very old. This model suggests focusing on individuals with good cognition despite prolonged high risk when seeking protective factors. |
| format | Article |
| id | doaj-art-fb133743a3fd40a0bc9a2d47171b0a96 |
| institution | DOAJ |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-fb133743a3fd40a0bc9a2d47171b0a962025-08-20T03:22:00ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-015192693210.1016/j.trci.2019.11.009Associations of hemoglobin A1c with cognition reduced for long diabetes durationJeremy M. Silverman0James Schmeidler1Pearl G. Lee2Neil B. Alexander3Michal Schnaider Beeri4Elizabeth Guerrero‐Berroa5Rebecca K. West6Mary Sano7Martina Nabozny8Carolina Rodriguez Alvarez9Research & DevelopmentJames J. Peters Veterans Affairs Medical CenterBronxNYUSADepartment of PsychiatryIcahn School of Medicine at Mount SinaiNew YorkNYUSADepartment of Internal Medicine and Division of Geriatric and Palliative MedicineUniversity of MichiganAnn ArborMIUSADepartment of Internal Medicine and Division of Geriatric and Palliative MedicineUniversity of MichiganAnn ArborMIUSADepartment of PsychiatryIcahn School of Medicine at Mount SinaiNew YorkNYUSADepartment of PsychiatryIcahn School of Medicine at Mount SinaiNew YorkNYUSADepartment of PsychiatryIcahn School of Medicine at Mount SinaiNew YorkNYUSAResearch & DevelopmentJames J. Peters Veterans Affairs Medical CenterBronxNYUSADepartment of Internal Medicine and Division of Geriatric and Palliative MedicineUniversity of MichiganAnn ArborMIUSADepartment of PsychiatryIcahn School of Medicine at Mount SinaiNew YorkNYUSAAbstract Introduction Associations of some risk factors with poor cognition, identified prior to age 75, are reduced or reversed in very old age. The Protected Survivor Model predicts this interaction due to enhanced survival of those with extended risk factor duration. In a younger sample, this study examines the association of cognition with the mean hemoglobin A1c risk factor over the time at risk, according to its duration. Methods The interaction of mean hemoglobin A1c (average = 9.8%), evaluated over duration (average = 116.8 months), was examined for overall cognition and three cognitive domains in a sample of 150 “young‐old” veterans (mean age = 70) with type 2 diabetes. Results The predicted interactions were significant for overall cognition and attention, but not executive functions/language and memory. Discussion Findings extend the Protected Survivor Model to a “young‐old” sample, from the very old. This model suggests focusing on individuals with good cognition despite prolonged high risk when seeking protective factors.https://doi.org/10.1016/j.trci.2019.11.009Type 2 diabetesDiabetes durationHemoglobin A1cCognitive functionRisk factorsProtective factors |
| spellingShingle | Jeremy M. Silverman James Schmeidler Pearl G. Lee Neil B. Alexander Michal Schnaider Beeri Elizabeth Guerrero‐Berroa Rebecca K. West Mary Sano Martina Nabozny Carolina Rodriguez Alvarez Associations of hemoglobin A1c with cognition reduced for long diabetes duration Alzheimer’s & Dementia: Translational Research & Clinical Interventions Type 2 diabetes Diabetes duration Hemoglobin A1c Cognitive function Risk factors Protective factors |
| title | Associations of hemoglobin A1c with cognition reduced for long diabetes duration |
| title_full | Associations of hemoglobin A1c with cognition reduced for long diabetes duration |
| title_fullStr | Associations of hemoglobin A1c with cognition reduced for long diabetes duration |
| title_full_unstemmed | Associations of hemoglobin A1c with cognition reduced for long diabetes duration |
| title_short | Associations of hemoglobin A1c with cognition reduced for long diabetes duration |
| title_sort | associations of hemoglobin a1c with cognition reduced for long diabetes duration |
| topic | Type 2 diabetes Diabetes duration Hemoglobin A1c Cognitive function Risk factors Protective factors |
| url | https://doi.org/10.1016/j.trci.2019.11.009 |
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