Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives
Takotsubo syndrome (TTS) is an acute coronary syndrome of unknown prevalence with a physiopathological mechanism that is not yet fully understood. The course is generally benign. Current therapeutic management is based on limited evidence. Oxidative stress seems to play a role in the pathogenesis of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/5/522 |
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| author | Alfredo Mauriello Carmen Del Giudice Gerardo Elia Del Vecchio Adriana Correra Anna Chiara Maratea Martina Grieco Arianna Amata Vincenzo Quagliariello Nicola Maurea Riccardo Proietti Antonio Giordano Antonello D’Andrea Vincenzo Russo |
| author_facet | Alfredo Mauriello Carmen Del Giudice Gerardo Elia Del Vecchio Adriana Correra Anna Chiara Maratea Martina Grieco Arianna Amata Vincenzo Quagliariello Nicola Maurea Riccardo Proietti Antonio Giordano Antonello D’Andrea Vincenzo Russo |
| author_sort | Alfredo Mauriello |
| collection | DOAJ |
| description | Takotsubo syndrome (TTS) is an acute coronary syndrome of unknown prevalence with a physiopathological mechanism that is not yet fully understood. The course is generally benign. Current therapeutic management is based on limited evidence. Oxidative stress seems to play a role in the pathogenesis of cardiovascular diseases, especially regarding the endothelial dysfunction underlying TTS. The present review aims to describe the pathophysiological mechanisms linking oxidative stress and TTS, explore the impact of oxidative stress on TTS, and evaluate the efficacy of anti-oxidative stress therapies on TTS. |
| format | Article |
| id | doaj-art-fb0fa24d45ac4bd7bda1bb916f1d3c35 |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-fb0fa24d45ac4bd7bda1bb916f1d3c352025-08-20T03:14:29ZengMDPI AGAntioxidants2076-39212025-04-0114552210.3390/antiox14050522Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future PerspectivesAlfredo Mauriello0Carmen Del Giudice1Gerardo Elia Del Vecchio2Adriana Correra3Anna Chiara Maratea4Martina Grieco5Arianna Amata6Vincenzo Quagliariello7Nicola Maurea8Riccardo Proietti9Antonio Giordano10Antonello D’Andrea11Vincenzo Russo12S.C. Cardiologia, Istituto Nazionale Tumori, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyCardiology Unit, Boscotrecase Hospital, ASL NA3Sud, 81042 Boscotrecase, ItalyCardiology Unit, “A. Guerriero” Hospital, ASL CE, 81025 Marcianise, ItalyIntensive Cardiac Care Unit, “San Giuseppe Moscati” Hospital, ASL CE, 81031 Aversa, ItalyS.C. Cardiologia, Istituto Nazionale Tumori, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyCardiology Unit, S. Giovanni Bosco Hospital, ASL NA1, 80100 Naples, ItalyDepartment of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyS.C. Cardiologia, Istituto Nazionale Tumori, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyS.C. Cardiologia, Istituto Nazionale Tumori, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool L8 7TX, UKSbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg, Suite 431-1900 N 12th Street, Philadelphia, PA 19122, USACardiology and Intensive Care Unit, Department of Cardiology, “Umberto I” Hospital, 84014 Nocera Inferiore, ItalyCardiology Unit, Department of Medical and Translational Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyTakotsubo syndrome (TTS) is an acute coronary syndrome of unknown prevalence with a physiopathological mechanism that is not yet fully understood. The course is generally benign. Current therapeutic management is based on limited evidence. Oxidative stress seems to play a role in the pathogenesis of cardiovascular diseases, especially regarding the endothelial dysfunction underlying TTS. The present review aims to describe the pathophysiological mechanisms linking oxidative stress and TTS, explore the impact of oxidative stress on TTS, and evaluate the efficacy of anti-oxidative stress therapies on TTS.https://www.mdpi.com/2076-3921/14/5/522Takotsubo syndromeoxidative stressacute coronary syndromeheart failurecancer |
| spellingShingle | Alfredo Mauriello Carmen Del Giudice Gerardo Elia Del Vecchio Adriana Correra Anna Chiara Maratea Martina Grieco Arianna Amata Vincenzo Quagliariello Nicola Maurea Riccardo Proietti Antonio Giordano Antonello D’Andrea Vincenzo Russo Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives Antioxidants Takotsubo syndrome oxidative stress acute coronary syndrome heart failure cancer |
| title | Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives |
| title_full | Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives |
| title_fullStr | Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives |
| title_full_unstemmed | Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives |
| title_short | Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives |
| title_sort | takotsubo syndrome and oxidative stress physiopathological linkage and future perspectives |
| topic | Takotsubo syndrome oxidative stress acute coronary syndrome heart failure cancer |
| url | https://www.mdpi.com/2076-3921/14/5/522 |
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