Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema
Abstract Background Angioedema (AE) rarely occurs as a potentially life‐threatening adverse drug reaction (ADR) to angiotensin‐converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). The aim of the present study was to investigate non‐genetic association factors with ACEi‐/ARB‐in...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
|
| Series: | Clinical and Translational Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/clt2.70058 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849719724225593344 |
|---|---|
| author | Diana Dubrall Nora L. Branding Carina M. Mathey Anna M. Weber Michael Steffens Maike Below Matthias Schmid Bettina Wedi Dorothea Wieczorek Philipp M. Amann Harald Löffler Lukas Koch Clemens Schöffl Heinrich Dickel Nomun Ganjuur Thorsten Hornung Timo Buhl Emel Aygören‐Pürsün Gerda Wurpts Jens Greve Markus M. Nöthen Andreas J. Forstner Bernhardt Sachs |
| author_facet | Diana Dubrall Nora L. Branding Carina M. Mathey Anna M. Weber Michael Steffens Maike Below Matthias Schmid Bettina Wedi Dorothea Wieczorek Philipp M. Amann Harald Löffler Lukas Koch Clemens Schöffl Heinrich Dickel Nomun Ganjuur Thorsten Hornung Timo Buhl Emel Aygören‐Pürsün Gerda Wurpts Jens Greve Markus M. Nöthen Andreas J. Forstner Bernhardt Sachs |
| author_sort | Diana Dubrall |
| collection | DOAJ |
| description | Abstract Background Angioedema (AE) rarely occurs as a potentially life‐threatening adverse drug reaction (ADR) to angiotensin‐converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). The aim of the present study was to investigate non‐genetic association factors with ACEi‐/ARB‐induced angioedema in the European ADR database EudraVigilance and the database of the vARIANCE study. Methods The cohort of the vARIANCE study comprised 114 patients who suffered from ACEi‐ or ARB‐induced angioedema. In addition, 171 angioedema reports and 4650 reports on other ADRs of ACEi/ARB were identified in the ADR database EudraVigilance with the latter serving as a reference group. Odds ratios were calculated and a logistic regression analysis was performed using angioedema versus reference reports. Results Increased age, smoking, allergies and a history of previous angioedema were identified as associated factors for ACEi‐/ARB‐induced angioedema. In most patients, the swelling affected the face, lips and tongue. In the vARIANCE study, about 70% of angioedema occurred after 1 year of treatment. For one in two patients in the vARIANCE study (84.2% with ACEi treatment) and one in three patients from the EudraVigilance reports (59.6% with ARB treatment), the angioedema resulted in hospitalization. Conclusions We found small to moderate associations with certain individual patient‐related factors in this pharmaco‐epidemiological study. As a future perspective, combining non‐genetic association factors with corresponding genetic data might provide an option to compose stronger and individual risk scores. |
| format | Article |
| id | doaj-art-fb0dea07a33140e28552eb541f5aab01 |
| institution | DOAJ |
| issn | 2045-7022 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj-art-fb0dea07a33140e28552eb541f5aab012025-08-20T03:12:05ZengWileyClinical and Translational Allergy2045-70222025-05-01155n/an/a10.1002/clt2.70058Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedemaDiana Dubrall0Nora L. Branding1Carina M. Mathey2Anna M. Weber3Michael Steffens4Maike Below5Matthias Schmid6Bettina Wedi7Dorothea Wieczorek8Philipp M. Amann9Harald Löffler10Lukas Koch11Clemens Schöffl12Heinrich Dickel13Nomun Ganjuur14Thorsten Hornung15Timo Buhl16Emel Aygören‐Pürsün17Gerda Wurpts18Jens Greve19Markus M. Nöthen20Andreas J. Forstner21Bernhardt Sachs22Institute for Medical Biometry Informatics and Epidemiology University Hospital of Bonn Bonn GermanyResearch Division Federal Institute of Drugs and Medical Devices (BfArM) Bonn GermanyResearch Division Federal Institute of Drugs and Medical Devices (BfArM) Bonn GermanyResearch Division Federal Institute of Drugs and Medical Devices (BfArM) Bonn GermanyResearch Division Federal Institute of Drugs and Medical Devices (BfArM) Bonn GermanyCentral Research Institute for Ambulatory Health Care in Germany Berlin GermanyInstitute for Medical Biometry Informatics and Epidemiology University Hospital of Bonn Bonn GermanyKlinik für Dermatologie Allergologie und Venerologie Medizinische Hochschule Hannover Hannover GermanyKlinik für Dermatologie Allergologie und Venerologie Medizinische Hochschule Hannover Hannover GermanyKlinik für Dermatologie Allergologie und Phlebologie SLK‐Kliniken Heilbronn Heilbronn GermanyKlinik für Dermatologie Allergologie und Phlebologie SLK‐Kliniken Heilbronn Heilbronn GermanyDepartment of Dermatology and Venereology Medical University of Graz Graz AustriaDepartment of Dermatology and Venereology Medical University of Graz Graz AustriaDepartment of Dermatology, Venereology and Allergology St. Josef Hospital University Medical Center Ruhr University Bochum Bochum GermanyDepartment of Dermatology, Venereology and Allergology St. Josef Hospital University Medical Center Ruhr University Bochum Bochum GermanyZentrum für Hauterkrankungen Universitätsklinikum Bonn Bonn GermanyKlinik für Dermatologie Venerologie und Allergologie Universitätsmedizin Göttingen Göttingen GermanyDepartment of Pediatrics Goethe University Frankfurt Frankfurt GermanyKlinik für Dermatologie und Allergologie ‐ Hautklinik Universitätsklinik der RWTH Aachen Aachen GermanyDepartment of Otorhinolaryngology—Head and Neck Surgery Ulm University Medical Center Ulm GermanyInstitute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn GermanyInstitute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn GermanyResearch Division Federal Institute of Drugs and Medical Devices (BfArM) Bonn GermanyAbstract Background Angioedema (AE) rarely occurs as a potentially life‐threatening adverse drug reaction (ADR) to angiotensin‐converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). The aim of the present study was to investigate non‐genetic association factors with ACEi‐/ARB‐induced angioedema in the European ADR database EudraVigilance and the database of the vARIANCE study. Methods The cohort of the vARIANCE study comprised 114 patients who suffered from ACEi‐ or ARB‐induced angioedema. In addition, 171 angioedema reports and 4650 reports on other ADRs of ACEi/ARB were identified in the ADR database EudraVigilance with the latter serving as a reference group. Odds ratios were calculated and a logistic regression analysis was performed using angioedema versus reference reports. Results Increased age, smoking, allergies and a history of previous angioedema were identified as associated factors for ACEi‐/ARB‐induced angioedema. In most patients, the swelling affected the face, lips and tongue. In the vARIANCE study, about 70% of angioedema occurred after 1 year of treatment. For one in two patients in the vARIANCE study (84.2% with ACEi treatment) and one in three patients from the EudraVigilance reports (59.6% with ARB treatment), the angioedema resulted in hospitalization. Conclusions We found small to moderate associations with certain individual patient‐related factors in this pharmaco‐epidemiological study. As a future perspective, combining non‐genetic association factors with corresponding genetic data might provide an option to compose stronger and individual risk scores.https://doi.org/10.1002/clt2.70058angioedemaangiotensin‐converting enzyme inhibitorsangiotensin‐receptor blockersdrug‐induced angioedemaspontaneous reports |
| spellingShingle | Diana Dubrall Nora L. Branding Carina M. Mathey Anna M. Weber Michael Steffens Maike Below Matthias Schmid Bettina Wedi Dorothea Wieczorek Philipp M. Amann Harald Löffler Lukas Koch Clemens Schöffl Heinrich Dickel Nomun Ganjuur Thorsten Hornung Timo Buhl Emel Aygören‐Pürsün Gerda Wurpts Jens Greve Markus M. Nöthen Andreas J. Forstner Bernhardt Sachs Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema Clinical and Translational Allergy angioedema angiotensin‐converting enzyme inhibitors angiotensin‐receptor blockers drug‐induced angioedema spontaneous reports |
| title | Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema |
| title_full | Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema |
| title_fullStr | Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema |
| title_full_unstemmed | Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema |
| title_short | Non‐genetic factors associated with ACE‐inhibitor and angiotensin receptor blocker‐induced angioedema |
| title_sort | non genetic factors associated with ace inhibitor and angiotensin receptor blocker induced angioedema |
| topic | angioedema angiotensin‐converting enzyme inhibitors angiotensin‐receptor blockers drug‐induced angioedema spontaneous reports |
| url | https://doi.org/10.1002/clt2.70058 |
| work_keys_str_mv | AT dianadubrall nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT noralbranding nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT carinammathey nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT annamweber nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT michaelsteffens nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT maikebelow nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT matthiasschmid nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT bettinawedi nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT dorotheawieczorek nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT philippmamann nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT haraldloffler nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT lukaskoch nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT clemensschoffl nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT heinrichdickel nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT nomunganjuur nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT thorstenhornung nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT timobuhl nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT emelaygorenpursun nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT gerdawurpts nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT jensgreve nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT markusmnothen nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT andreasjforstner nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema AT bernhardtsachs nongeneticfactorsassociatedwithaceinhibitorandangiotensinreceptorblockerinducedangioedema |