Regulating the metabolic flux of pyruvate dehydrogenase bypass to enhance lipid production in Saccharomyces cerevisiae

Abstract To achieve high efficiency in microbial cell factories, it is crucial to redesign central carbon fluxes to ensure an adequate supply of precursors for producing high-value compounds. In this study, we employed a multi-omics approach to rearrange the central carbon flux of the pyruvate dehyd...

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Bibliographic Details
Main Authors: Cairong Lei, Xiaopeng Guo, Miaomiao Zhang, Xiang Zhou, Nan Ding, Junle Ren, Meihan Liu, Chenglin Jia, Yajuan Wang, Jingru Zhao, Ziyi Dong, Dong Lu
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07103-7
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