USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4

USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4

Abstract In mouse, minor zygotic genome activation (ZGA) precedes and is essential for major ZGA in two-cell (2C) embryos. A subset of ZGA genes (known as “2C” genes) are also activated in a rare population of embryonic stem cells (ESCs) (2C-like cells). However, the functions of the 2C genes are no...

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Bibliographic Details
Main Authors: Panpan Shi, Xukun Lu, Kairang Jin, Linlin Liu, Guoxing Yin, Wenying Wang, Jiao Yang, Lijuan Wang, Lijun Dong, Wei Xie, Lin Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62303-x
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