Immunomodulatory Effects of Aerobic Training in Obesity
Introduction. Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) an...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/308965 |
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| author | Thomas Nickel Henner Hanssen Ingrid Emslander Verena Drexel Gernot Hertel Arno Schmidt-Trucksäss Claudia Summo Zeljka Sisic Marius Lambert Eva Hoster Martin Halle Michael Weis |
| author_facet | Thomas Nickel Henner Hanssen Ingrid Emslander Verena Drexel Gernot Hertel Arno Schmidt-Trucksäss Claudia Summo Zeljka Sisic Marius Lambert Eva Hoster Martin Halle Michael Weis |
| author_sort | Thomas Nickel |
| collection | DOAJ |
| description | Introduction. Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week). Methods. Circulating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression. TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot. Circulating oxLDL levels were analyzed by ELISA. Results. BDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; 𝑃<.05), but significantly increased in ONE after training (+50%; 𝑃<.05). In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; 𝑃<.05) and decreased in ONE after the 10-week training period (−27%; 𝑃<.05). Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (𝑃<.01/𝑃<.05) compared to pre training. A reduction of oxLDL levels was seen in ONE (−61%; 𝑃<.05). Conclusions. Intensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes. We hereby describe new immune modulatory effects, which—through regular aerobic exercise—modulate innate immunity and pro-inflammatory cytokines in obesity. |
| format | Article |
| id | doaj-art-fb0618a7b01e42358042e34c24c5fcbd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fb0618a7b01e42358042e34c24c5fcbd2025-02-03T05:58:07ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/308965308965Immunomodulatory Effects of Aerobic Training in ObesityThomas Nickel0Henner Hanssen1Ingrid Emslander2Verena Drexel3Gernot Hertel4Arno Schmidt-Trucksäss5Claudia Summo6Zeljka Sisic7Marius Lambert8Eva Hoster9Martin Halle10Michael Weis11Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, GermanyDepartment of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, GermanyDepartment of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, GermanyDepartment of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, GermanyDepartment of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, GermanySports Medicine, Institute of Exercise and Health Sciences, University Basel, 4003 Basel, SwitzerlandMedizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, GermanyMedizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, GermanyMedizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, GermanyInstitute for Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians-Universität München, 81377 Munich, GermanyDepartment of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, GermanyMedizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, GermanyIntroduction. Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week). Methods. Circulating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression. TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot. Circulating oxLDL levels were analyzed by ELISA. Results. BDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; 𝑃<.05), but significantly increased in ONE after training (+50%; 𝑃<.05). In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; 𝑃<.05) and decreased in ONE after the 10-week training period (−27%; 𝑃<.05). Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (𝑃<.01/𝑃<.05) compared to pre training. A reduction of oxLDL levels was seen in ONE (−61%; 𝑃<.05). Conclusions. Intensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes. We hereby describe new immune modulatory effects, which—through regular aerobic exercise—modulate innate immunity and pro-inflammatory cytokines in obesity.http://dx.doi.org/10.1155/2011/308965 |
| spellingShingle | Thomas Nickel Henner Hanssen Ingrid Emslander Verena Drexel Gernot Hertel Arno Schmidt-Trucksäss Claudia Summo Zeljka Sisic Marius Lambert Eva Hoster Martin Halle Michael Weis Immunomodulatory Effects of Aerobic Training in Obesity Mediators of Inflammation |
| title | Immunomodulatory Effects of Aerobic Training in Obesity |
| title_full | Immunomodulatory Effects of Aerobic Training in Obesity |
| title_fullStr | Immunomodulatory Effects of Aerobic Training in Obesity |
| title_full_unstemmed | Immunomodulatory Effects of Aerobic Training in Obesity |
| title_short | Immunomodulatory Effects of Aerobic Training in Obesity |
| title_sort | immunomodulatory effects of aerobic training in obesity |
| url | http://dx.doi.org/10.1155/2011/308965 |
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