The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative disease
The gut microbiota, a complex community of microorganisms residing in the digestive tract, plays a pivotal role in human health. Recent studies have highlighted its significant impact on neurodegenerative diseases, conditions that pose profound challenges to affected individuals and society at large...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242125000806 |
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| author | Nour Abou Izzeddine Kawsar Ahmad Christine Bacha Maria Jabbour Mouin Najjar Sethrida Salhab Hilda E. Ghadieh Amjad Kanaan Sami Azar Ziad Abi Khattar Frederic Harb |
| author_facet | Nour Abou Izzeddine Kawsar Ahmad Christine Bacha Maria Jabbour Mouin Najjar Sethrida Salhab Hilda E. Ghadieh Amjad Kanaan Sami Azar Ziad Abi Khattar Frederic Harb |
| author_sort | Nour Abou Izzeddine |
| collection | DOAJ |
| description | The gut microbiota, a complex community of microorganisms residing in the digestive tract, plays a pivotal role in human health. Recent studies have highlighted its significant impact on neurodegenerative diseases, conditions that pose profound challenges to affected individuals and society at large. This review explores the intricate relationship between gut microbiota and the progression of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington’s disease, and Amyotrophic Lateral Sclerosis. We delve into the dynamic ecosystem of gut microbiota, examining factors influencing its composition and the bidirectional communication established via the gut-brain axis. Emerging evidence suggests that gut microbiota can modulate neurodegenerative disease progression through mechanisms including inflammatory responses, production of neuroactive substances, and regulation of neurotransmitters. Furthermore, we discuss the potential therapeutic implications of targeting gut microbiota with probiotics, prebiotics, and postbiotics. While promising, these interventions face challenges and limitations that must be addressed through ongoing research. Understanding the role of gut microbiota in neurodegenerative diseases is crucial for developing innovative therapeutic strategies and improving patient outcomes. |
| format | Article |
| id | doaj-art-fb0163829fb44ab59a8cee4e61a48b90 |
| institution | OA Journals |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-fb0163829fb44ab59a8cee4e61a48b902025-08-20T02:32:23ZengElsevierIBRO Neuroscience Reports2667-24212025-12-0119173710.1016/j.ibneur.2025.05.014The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative diseaseNour Abou Izzeddine0Kawsar Ahmad1Christine Bacha2Maria Jabbour3Mouin Najjar4Sethrida Salhab5Hilda E. Ghadieh6Amjad Kanaan7Sami Azar8Ziad Abi Khattar9Frederic Harb10Columbia College, Columbia University, 116th and Broadway, New York, NY 10027, USADepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, LebanonDepartment of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, Lebanon; Corresponding authors.Department of Biomedical Sciences, University of Balamand, Faculty of Medicine and Medical Sciences, P.O. Box 100, Tripoli, Lebanon; Corresponding authors.The gut microbiota, a complex community of microorganisms residing in the digestive tract, plays a pivotal role in human health. Recent studies have highlighted its significant impact on neurodegenerative diseases, conditions that pose profound challenges to affected individuals and society at large. This review explores the intricate relationship between gut microbiota and the progression of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington’s disease, and Amyotrophic Lateral Sclerosis. We delve into the dynamic ecosystem of gut microbiota, examining factors influencing its composition and the bidirectional communication established via the gut-brain axis. Emerging evidence suggests that gut microbiota can modulate neurodegenerative disease progression through mechanisms including inflammatory responses, production of neuroactive substances, and regulation of neurotransmitters. Furthermore, we discuss the potential therapeutic implications of targeting gut microbiota with probiotics, prebiotics, and postbiotics. While promising, these interventions face challenges and limitations that must be addressed through ongoing research. Understanding the role of gut microbiota in neurodegenerative diseases is crucial for developing innovative therapeutic strategies and improving patient outcomes.http://www.sciencedirect.com/science/article/pii/S2667242125000806Gut microbiotaNeurodegenerative diseasesGut-brain axisInflammationProbioticsNeuroactive substances |
| spellingShingle | Nour Abou Izzeddine Kawsar Ahmad Christine Bacha Maria Jabbour Mouin Najjar Sethrida Salhab Hilda E. Ghadieh Amjad Kanaan Sami Azar Ziad Abi Khattar Frederic Harb The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative disease IBRO Neuroscience Reports Gut microbiota Neurodegenerative diseases Gut-brain axis Inflammation Probiotics Neuroactive substances |
| title | The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative disease |
| title_full | The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative disease |
| title_fullStr | The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative disease |
| title_full_unstemmed | The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative disease |
| title_short | The microbial guardians: Unveiling the role of gut microbiota in shaping neurodegenerative disease |
| title_sort | microbial guardians unveiling the role of gut microbiota in shaping neurodegenerative disease |
| topic | Gut microbiota Neurodegenerative diseases Gut-brain axis Inflammation Probiotics Neuroactive substances |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125000806 |
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