Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model

Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model

Abstract Despite the major roles of choroid plexus epithelial cells (CPECs) in brain homeostasis and repair, their developmental lineage and diversity remain undefined. In simplified differentiations from human pluripotent stem cells, derived CPECs (dCPECs) display canonical properties and dynamic m...

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Bibliographic Details
Main Authors: Haley Masters, Shuxiong Wang, Christina Tu, Quy Nguyen, Yutong Sha, Matthew K. Karikomi, Pamela Shi Ru Fung, Benjamin Tran, Cristina Martel, Nellie Kwang, Michael Neel, Olga G. Jaime, Victoria Espericueta, Brett A. Johnson, Kai Kessenbrock, Qing Nie, Edwin S. Monuki
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60361-9
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