Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
Nickel and copper complexes of ethambutol [EB] were synthesized and characterized. On the basis of spectral and thermal data an octahedral geometry was assigned to the complexes with molecular formulae [Cu(C10 H24 N2 O2)2Cl2] 5H2O and [Ni(C10 H24 N2 O2)2Cl2] 2H2O. Coordination of ethylene diamine de...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2006/476513 |
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| Summary: | Nickel and copper complexes of ethambutol [EB] were synthesized and characterized. On the basis of spectral and thermal data an octahedral geometry was assigned to the complexes with molecular formulae [Cu(C10 H24 N2 O2)2Cl2] 5H2O and [Ni(C10 H24 N2 O2)2Cl2] 2H2O. Coordination of ethylene diamine derivative to the metal ion was proposed. The anti-tubercular activity of the complexes was evaluated using Lowenstein–Jensen medium and MABA [Microplate Alamar Blue Assay] methods. |
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| ISSN: | 0973-4945 2090-9810 |