Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant Disinfection
Abstract Non‐invasive light‐based antibacterial therapy has a good prospect in non‐surgical treatment of peri‐implant infections. However, its applications are severely limited by poor penetration of light into human tissues, leading to unsatisfying outcomes. Moreover, as an essential prerequisite f...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202203472 |
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| author | Ludan Zhang Yamin Li Lintian Yuan Qianyi Zhang Yuqing Yan Fan Dong Jun Tang Yuguang Wang |
| author_facet | Ludan Zhang Yamin Li Lintian Yuan Qianyi Zhang Yuqing Yan Fan Dong Jun Tang Yuguang Wang |
| author_sort | Ludan Zhang |
| collection | DOAJ |
| description | Abstract Non‐invasive light‐based antibacterial therapy has a good prospect in non‐surgical treatment of peri‐implant infections. However, its applications are severely limited by poor penetration of light into human tissues, leading to unsatisfying outcomes. Moreover, as an essential prerequisite for traditional light therapy, lasers can no longer meet the patients’ needs for convenient treatment at any time. To break through the spatial and temporal limitations of traditional light therapy, a wireless‐powered blue‐light zirconia implant for readily available treatment of peri‐implant infection is proposed. In space, complete irradiation to complex peri‐implant structure is realized by the built‐in wireless‐powered light source, thus improving the efficacy. In time, wireless‐powering allows timely and controllable anti‐infection treatment. Blue micro‐light emitting diodes are used as therapeutic light sources, which effectively kill peri‐implant infection‐related bacteria without exogenous photosensitive agents. Porphyromonas gingivalis biofilm on implant surface can be completely killed after 20 min irradiation in vitro. The bactericidal rate of peri‐implant methicillin‐resistant Staphylococcus aureus infection reaches 99.96 ± 0.03% under 30 min per day blue light exposure in vivo. Within the scope of this study, the treatment of peri‐implant infection with blue‐light implant has preliminary feasibility, giving a new approach to non‐invasive treatment of deep oral infections, including peri‐implant infections. |
| format | Article |
| id | doaj-art-faec67c87b4149c594d6c3bcf443e559 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-faec67c87b4149c594d6c3bcf443e5592025-08-20T03:36:45ZengWileyAdvanced Science2198-38442023-05-011014n/an/a10.1002/advs.202203472Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant DisinfectionLudan Zhang0Yamin Li1Lintian Yuan2Qianyi Zhang3Yuqing Yan4Fan Dong5Jun Tang6Yuguang Wang7Center of Digital Dentistry/ Department of Prosthodontics National Center of Stomatology National Clinical Research Center for Oral Diseases National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology NHC Research Center of Engineering and Technology for Computerized Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. ChinaState Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 P. R. ChinaCenter of Digital Dentistry/ Department of Prosthodontics National Center of Stomatology National Clinical Research Center for Oral Diseases National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology NHC Research Center of Engineering and Technology for Computerized Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. ChinaSchool of Materials Science and Engineering Tsinghua University Beijing 100084 P. R. ChinaBeijing Taia Technology Co. LTD Beijing 100089 P. R. ChinaCenter of Digital Dentistry/ Department of Prosthodontics National Center of Stomatology National Clinical Research Center for Oral Diseases National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology NHC Research Center of Engineering and Technology for Computerized Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. ChinaState Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 P. R. ChinaCenter of Digital Dentistry/ Department of Prosthodontics National Center of Stomatology National Clinical Research Center for Oral Diseases National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology NHC Research Center of Engineering and Technology for Computerized Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. ChinaAbstract Non‐invasive light‐based antibacterial therapy has a good prospect in non‐surgical treatment of peri‐implant infections. However, its applications are severely limited by poor penetration of light into human tissues, leading to unsatisfying outcomes. Moreover, as an essential prerequisite for traditional light therapy, lasers can no longer meet the patients’ needs for convenient treatment at any time. To break through the spatial and temporal limitations of traditional light therapy, a wireless‐powered blue‐light zirconia implant for readily available treatment of peri‐implant infection is proposed. In space, complete irradiation to complex peri‐implant structure is realized by the built‐in wireless‐powered light source, thus improving the efficacy. In time, wireless‐powering allows timely and controllable anti‐infection treatment. Blue micro‐light emitting diodes are used as therapeutic light sources, which effectively kill peri‐implant infection‐related bacteria without exogenous photosensitive agents. Porphyromonas gingivalis biofilm on implant surface can be completely killed after 20 min irradiation in vitro. The bactericidal rate of peri‐implant methicillin‐resistant Staphylococcus aureus infection reaches 99.96 ± 0.03% under 30 min per day blue light exposure in vivo. Within the scope of this study, the treatment of peri‐implant infection with blue‐light implant has preliminary feasibility, giving a new approach to non‐invasive treatment of deep oral infections, including peri‐implant infections.https://doi.org/10.1002/advs.202203472antimicrobial blue lightperi‐implant infectionswireless‐poweringzirconia implants |
| spellingShingle | Ludan Zhang Yamin Li Lintian Yuan Qianyi Zhang Yuqing Yan Fan Dong Jun Tang Yuguang Wang Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant Disinfection Advanced Science antimicrobial blue light peri‐implant infections wireless‐powering zirconia implants |
| title | Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant Disinfection |
| title_full | Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant Disinfection |
| title_fullStr | Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant Disinfection |
| title_full_unstemmed | Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant Disinfection |
| title_short | Advanced and Readily‐Available Wireless‐Powered Blue‐Light‐Implant for Non‐Invasive Peri‐Implant Disinfection |
| title_sort | advanced and readily available wireless powered blue light implant for non invasive peri implant disinfection |
| topic | antimicrobial blue light peri‐implant infections wireless‐powering zirconia implants |
| url | https://doi.org/10.1002/advs.202203472 |
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